{"title":"IgE in Allergic Diseases","authors":"Dana Greene, Jamie Moore Fried, Julie Wang","doi":"10.1111/imr.70057","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of antigen-specific IgE leads to rapid degranulation and release of histamine, leukotrienes, and other mediators, resulting in classic allergic sequelae. IgE plays a key role in conditions including food allergy, atopic dermatitis, asthma, chronic spontaneous urticaria, and chronic rhinosinusitis. Clinical applications of anti-IgE targeted therapies have demonstrated effectiveness in improving outcomes in food allergy desensitization, reducing asthma exacerbations, and treating chronic urticaria. This review highlights the critical role of IgE as a therapeutic and diagnostic target in the management of allergic disease.</p>\n </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"334 1","pages":""},"PeriodicalIF":8.3000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological Reviews","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/imr.70057","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of antigen-specific IgE leads to rapid degranulation and release of histamine, leukotrienes, and other mediators, resulting in classic allergic sequelae. IgE plays a key role in conditions including food allergy, atopic dermatitis, asthma, chronic spontaneous urticaria, and chronic rhinosinusitis. Clinical applications of anti-IgE targeted therapies have demonstrated effectiveness in improving outcomes in food allergy desensitization, reducing asthma exacerbations, and treating chronic urticaria. This review highlights the critical role of IgE as a therapeutic and diagnostic target in the management of allergic disease.
期刊介绍：
Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system.
The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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