Prospects, Advances, and Applications of BioMOF-Based Platforms

IF 8.8 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2025-08-27 DOI:10.1007/s41061-025-00512-0

Fangxia Zhao, Xunnan Wan, Yan Liang, Weidong Liu, Jianqiang Liu, Ying Pan, Alireza Nezamzadeh-Ejhieh, Xiaoxiu Li

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引用次数: 0

Abstract

Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host–guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure–property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail. Finally, in terms of future perspectives, we discuss emerging opportunities in other delivery systems, personalized medicine platforms, and sustainable environmental applications, underscoring the necessity for cross-disciplinary collaboration between materials science and molecular biology to unlock the full potential of these biohybrid systems.

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生物燃料平台的前景、进展和应用

生物金属-有机框架（bio-MOFs）是一种革命性的混合材料，以其卓越的生物相容性、可编程生物降解性和主客体分子识别能力而著称。本文系统地回顾了生物mof工程的最新进展，特别关注了创新的合成策略以及由其可调孔结构和表面功能引起的结构-性能关系。详细讨论了生物mofs在靶向药物传递系统、对比增强生物成像和结合抗炎和抗菌作用的多功能治疗干预中的机制基础。最后，就未来前景而言，我们讨论了其他输送系统，个性化医疗平台和可持续环境应用中的新兴机会，强调了材料科学和分子生物学之间跨学科合作的必要性，以释放这些生物混合系统的全部潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.