Cobalt-catalyzed N–F bond activation for hydroamination of diazocarbonyl compounds with NFSI

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-08-22 DOI:10.1016/j.tet.2025.134895

Rongxiang Chen, Bingyang Wu, Wenya Liu, Jutuan Xiao, Kai-Kai Wang

引用次数: 0

Abstract

A hydroamination of diazocarbonyl compounds with NFSI under cobalt catalysis is reported. In this strategy, radical reaction occurred through the cleavage/activation of N–F bond with cobalt carbene. The reaction can be performed under mild conditions, good functional group tolerance and excellent yield. The synthetic scope involves a wide variety of diazoketones and α-diazoesters. The mechanism study showed that the reaction may undergo a radical process.

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钴催化N-F键活化重氮羰基化合物与NFSI的氢胺化

报道了在钴催化下用NFSI进行重氮羰基化合物的氢胺化反应。在该策略中，自由基反应是通过与羰基钴的N-F键的裂解/活化发生的。该反应条件温和，官能团耐受性好，产率高。合成范围涉及多种重氮酮类和α-重氮酯类。机理研究表明，该反应可能经历一个自由基过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.