Future Trends in Asymmetric Organo-Metal Combined Catalysis

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Central Science Pub Date : 2025-07-04 DOI:10.1021/acscentsci.5c00393

Dian-Feng Chen, Jin Song and Liu-Zhu Gong*,

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Abstract

Asymmetric organo-metal combined catalysis, which integrates the catalytic functions of chiral organocatalysts and metal complexes, enables the enantioselective formation of challenging chemical bonds and facilitates cascade transformations, often without the need for intermediate purification. Since its inception in 2001, this paradigm has evolved into a versatile strategy for the rapid construction of molecular complexity with a high level of enantioselectivity. In this Outlook, we have highlighted the most recent contributions to this field, showcasing exciting opportunities to overcome current efficiency limits. Looking ahead, we foresee the continued evolution of asymmetric organo-metal catalysis, particularly through the exploration of new catalyst scaffolds, the incorporation of external stimuli, the use of heterogeneous metal catalysts, and the application in macromolecular synthesis.

Asymmetric organo-metal combined catalysis has emerged as a versatile platform for enantioselective synthesis. This Outlook reviews the most recent contributions and foresees opportunities to pursue.

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不对称有机-金属复合催化的发展趋势

不对称有机-金属组合催化，集成了手性有机催化剂和金属配合物的催化功能，使具有挑战性的化学键的对映选择性形成和促进级联转化，通常不需要中间纯化。自2001年成立以来，这种模式已经发展成为一种快速构建具有高水平对映体选择性的分子复杂性的通用策略。在本展望中，我们重点介绍了该领域的最新贡献，展示了克服当前效率限制的令人兴奋的机会。展望未来，我们预计不对称有机金属催化将继续发展，特别是通过探索新的催化剂支架，外部刺激的结合，异相金属催化剂的使用，以及在大分子合成中的应用。不对称有机-金属组合催化已成为对映选择性合成的通用平台。本展望回顾了最近的贡献，并预测了追求的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Central Science Chemical Engineering-General Chemical Engineering

CiteScore

25.50

自引率

0.50%

发文量

194

审稿时长

10 weeks

期刊介绍： ACS Central Science publishes significant primary reports on research in chemistry and allied fields where chemical approaches are pivotal. As the first fully open-access journal by the American Chemical Society, it covers compelling and important contributions to the broad chemistry and scientific community. "Central science," a term popularized nearly 40 years ago, emphasizes chemistry's central role in connecting physical and life sciences, and fundamental sciences with applied disciplines like medicine and engineering. The journal focuses on exceptional quality articles, addressing advances in fundamental chemistry and interdisciplinary research.