Iron–sulfur cluster with double duty

IF 44.6 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2025-08-22 DOI:10.1038/s41929-025-01386-7

Olga A. Esakova, Squire J. Booker

引用次数: 0

Abstract

The radical S-adenosylmethionine (SAM) enzyme, AbmM, catalyses a replacement of the ring oxygen of a sugar with sulfur. However, how this reaction takes place is unknown. Now, an [Fe4S4] cluster is shown to have a dual role in catalysis. It functions in the reductive cleavage of SAM and is the donor of the appended sulfur atom.

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具有双重作用的铁硫簇

自由基s -腺苷甲硫氨酸（SAM）酶，AbmM，催化糖的环氧被硫取代。然而，这种反应是如何发生的尚不清楚。现在，一个[Fe4S4]簇被证明在催化中具有双重作用。它在SAM的还原裂解中起作用，并且是附加的硫原子的供体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

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