The actin cortex acts as a mechanical memory of morphology in confined migrating cells

IF 18.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY
Yohalie Kalukula, Marine Luciano, Gleb Simanov, Guillaume Charras, David B. Brückner, Sylvain Gabriele
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引用次数: 0

Abstract

Cell migration in narrow microenvironments occurs in numerous physiological processes. It involves successive cycles of confinement and release that drive important morphological changes. However, it remains unclear whether migrating cells can retain a memory of their past morphological states that could potentially facilitate their navigation through confined spaces. We demonstrate that local geometry governs a switch between two cell morphologies, thereby facilitating cell passage through long and narrow gaps. We combined cell migration assays on standardized microsystems with biophysical modelling and biochemical perturbations to show that migrating cells have a long-term memory of past confinement events. The morphological cell states correlate across transitions through actin cortex remodelling. These findings indicate that mechanical memory in migrating cells plays an active role in their migratory potential in confined environments. Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenvironments.

Abstract Image

Abstract Image

肌动蛋白皮层在受限的迁移细胞中充当形态的机械记忆
细胞在狭窄微环境中的迁移发生在许多生理过程中。它包括连续的封闭和释放循环,驱动重要的形态变化。然而,目前尚不清楚的是,迁移细胞是否能够保留过去形态状态的记忆,从而有可能促进它们在有限空间中的导航。我们证明了局部几何控制着两种细胞形态之间的切换,从而促进细胞通过长而窄的间隙。我们将标准化微系统上的细胞迁移实验与生物物理建模和生化扰动相结合,表明迁移细胞对过去的限制事件具有长期记忆。形态细胞状态通过肌动蛋白皮层重塑相互关联。这些发现表明,迁移细胞的机械记忆在受限环境下的迁移潜力中起着积极的作用。
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来源期刊
Nature Physics
Nature Physics 物理-物理:综合
CiteScore
30.40
自引率
2.00%
发文量
349
审稿时长
4-8 weeks
期刊介绍: Nature Physics is dedicated to publishing top-tier original research in physics with a fair and rigorous review process. It provides high visibility and access to a broad readership, maintaining high standards in copy editing and production, ensuring rapid publication, and maintaining independence from academic societies and other vested interests. The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.
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