Crispin Mukerebe, Alexandra A Cordeiro, Christine Aristide, Soledad Colombe, Brooke W Bullington, Samuel Kalluvya, Govert J van Dam, Claudia J de Dood, Paul L A M Corstjens, Jane K Maganga, John M Changalucha, Lucy A Namkinga, Victor Anacletus Makene, Myung Hee Lee, Jennifer A Downs
{"title":"Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota","authors":"Crispin Mukerebe, Alexandra A Cordeiro, Christine Aristide, Soledad Colombe, Brooke W Bullington, Samuel Kalluvya, Govert J van Dam, Claudia J de Dood, Paul L A M Corstjens, Jane K Maganga, John M Changalucha, Lucy A Namkinga, Victor Anacletus Makene, Myung Hee Lee, Jennifer A Downs","doi":"10.1093/infdis/jiaf447","DOIUrl":null,"url":null,"abstract":"Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiaf447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.
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