New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-08-23 DOI:10.1038/s41531-025-01113-w

Xingyue Chen, Guoxin Zhang, Miao Liu, Juanfeng He, Zhentao Zhang

引用次数: 0

Abstract

Exercise offers neuroprotective benefits in Parkinson’s disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.

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帕金森病运动诱导益处的分子机制新观点

运动通过增强神经营养因子（如BDNF、GDNF）、改善线粒体功能、减少炎症和促进自噬，对帕金森病（PD）具有神经保护作用。鸢尾素是一种肌肉来源的细胞因子，通过调节线粒体和减轻氧化应激，将运动与神经元健康联系起来。值得注意的是，鸢尾素可以作为无法运动的患者的治疗靶点。因此，运动是一种很有前景的非药物干预，需要进一步研究新的PD治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.