Exercise as a new therapeutic modality in oncology: CHALLENGE trial refines survivorship care

IF 82.2 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2025-08-26 DOI:10.1038/s41571-025-01071-5

Justin Y. Jeon

引用次数: 0

Abstract

The landmark CHALLENGE trial has revealed that a 3-year structured, behaviourally supported exercise intervention substantially improves both disease-free and overall survival in patients with resected phase II–III colon cancer, marking a genuine paradigm shift in survivorship care. By demonstrating modification of the course of disease rather than merely symptom alleviation, these results elevate exercise from ancillary support to evidence-based therapy and should compel oncology teams to embed expert-guided exercise into routine care.

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运动作为一种新的肿瘤治疗方式：CHALLENGE试验改善了生存护理

具有里程碑意义的CHALLENGE试验显示，为期3年的结构化、行为支持的运动干预可显著提高切除的II-III期结肠癌患者的无病生存期和总生存期，标志着生存护理的真正范式转变。通过证明改变病程而不仅仅是减轻症状，这些结果将运动从辅助支持提升到循证治疗，并应迫使肿瘤团队将专家指导的运动纳入常规护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.