Development of Resorbible Composites Based on Chitosan Fibers for Bone Grafting

IF 0.8 Q3 Engineering
N. A. Tagandurdyeva, G. V. Vaganov, I. P. Dobrovol’skaya, E. N. Dresvyanina, E. N. Popova, V. Yu. Elokhovskiy, V. E. Yudin, T. Wang
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Abstract

A method for producing composite materials for cranioplasty based on polylactide and poly-ε-caprolactone, which contain chitosan threads as a reinforcing filler, is described. Chitosan threads are obtained via wet spinning by precipitating acetic acid solutions of chitosan in an alcohol-alkaline medium. The melting temperatures of polylactide and poly-ε-caprolactone are significantly lower than the degradation temperature of chitosan, which makes it possible to obtain composite materials using heat-treatment methods, e.g., calendering and pressing. The composite material based on polylactide has strength and elastic characteristics close to those of cancellous bone tissue, and the composite based on poly-ε-caprolactone has those of cortical bone. This allows us to recommend the obtained composite materials for preclinical and clinical studies as bone-tissue implants, in pediatric cranioplasty for the treatment of injuries and diseases of the skull bones.

Abstract Image

Abstract Image

壳聚糖纤维再吸收复合材料的研究进展
本文介绍了一种以壳聚糖线为补强填料,以聚乳酸和聚ε-己内酯为基材,制备颅骨成形术用复合材料的方法。壳聚糖醋酸溶液在醇碱性介质中沉淀,采用湿法纺丝制得壳聚糖丝线。聚丙交酯和聚ε-己内酯的熔融温度明显低于壳聚糖的降解温度,这使得采用压延、压制等热处理方法获得复合材料成为可能。聚乳酸基复合材料具有接近松质骨组织的强度和弹性特性,聚ε-己内酯基复合材料具有皮质骨组织的强度和弹性特性。这使我们能够推荐获得的复合材料用于临床前和临床研究,作为骨组织植入物,用于治疗颅骨损伤和疾病的儿童颅骨成形术。
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来源期刊
Nanotechnologies in Russia
Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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