The role of small molecule metabolites in radiation-induced cardiovascular injury

Q1 Health Professions

Radiation Medicine and Protection Pub Date : 2025-08-01 DOI:10.1016/j.radmp.2025.06.003

Ziyi Guan, Nanxi Yu, Ruhan Yi, Ling Gao

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引用次数: 0

Abstract

Radiation exposure from medical exposure, occupational exposure, or accidental incidents, increases significant risks to cardiovascular health. Small molecule metabolites have attracted widespread attention owing to the role in cardiovascular cell metabolism, immune response and inflammatory injury. This article reviews the classification and characteristics of small molecule metabolites and their multiple roles in radiation-induced cardiovascular inflammatory injury. This article explored the potential of small molecule metabolites as biomarkers in the diagnosis and prognosis of cardiovascular diseases, and the potential as therapeutic targets. Based on the relevant research in recent years, this article summarizes the relationship between small molecule metabolites and cardiovascular inflammatory injury, as well as the mechanisms on the cardiovascular system under radiation, aiming to understand the potential mechanism of small molecule metabolites in radiation-induced cardiovascular diseases to develop new prevention and treatment strategies.

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小分子代谢物在辐射诱导的心血管损伤中的作用

来自医疗照射、职业照射或意外事件的辐射照射会显著增加心血管健康风险。小分子代谢物因其在心血管细胞代谢、免疫反应和炎症损伤中的作用而受到广泛关注。本文综述了小分子代谢物的分类、特点及其在辐射致心血管炎症损伤中的多重作用。本文探讨了小分子代谢物作为生物标志物在心血管疾病诊断和预后中的潜力，以及作为治疗靶点的潜力。本文在总结近年来相关研究的基础上，对辐射作用下小分子代谢物与心血管炎症损伤的关系及对心血管系统的作用机制进行综述，旨在了解小分子代谢物在辐射致心血管疾病中的潜在作用机制，从而制定新的防治策略。

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