Peripartum hypertension and neonatal outcomes across races: 2016-2022

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2025-08-20 DOI:10.1016/j.cpcardiol.2025.103152

Muhammad Shariq Usman MD , Ali Salman MBBS , Eliza Aisha MBBS , Uzair Khan MBBS , Sabina Naz MBBS , Sarah Faisal MBBS , Iqra Yaseen Khan MBBS , Muhammad Hammad Arif MBBS , Neha Mohiuddin MBBS , Ayesha Ali Khan MBBS , Ahson Afzal MBBS , Hamza Janjua MD , Farman Ali MD , Tariq Jamal Siddiqi MD

{"title":"Peripartum hypertension and neonatal outcomes across races: 2016-2022","authors":"Muhammad Shariq Usman MD , Ali Salman MBBS , Eliza Aisha MBBS , Uzair Khan MBBS , Sabina Naz MBBS , Sarah Faisal MBBS , Iqra Yaseen Khan MBBS , Muhammad Hammad Arif MBBS , Neha Mohiuddin MBBS , Ayesha Ali Khan MBBS , Ahson Afzal MBBS , Hamza Janjua MD , Farman Ali MD , Tariq Jamal Siddiqi MD","doi":"10.1016/j.cpcardiol.2025.103152","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Maternal hypertension, a major pregnancy complication, can adversely affect newborn health. Our study investigated racial/ethnic disparities in neonatal outcomes among hypertensive pregnant women in the US.</div></div><div><h3>Methods</h3><div>Using data from the CDC WONDER Natality database, we conducted a retrospective cohort study focusing on live births to hypertensive mothers from 2016 to 2022. We calculated rates [95% CI] per 1000 live births for NICU admissions, neonatal assisted ventilation, low birth weight, and in-hospital mortality across racial/ethnic groups and regions.</div></div><div><h3>Results</h3><div>We analyzed 2,392,664 live births to hypertensive women. In-hospital neonatal mortality rates were highest in Black American women (BA) (3.6 [3.5, 3.8]). Neonatal assisted ventilation rates were highest in Native Hawaiian/Pacific Islander women (NH/PI) (131.8 [123.4, 140.7]) and low birth weight rates were highest in BA (235.1 [233.9, 236.3]). Across all races, female neonates had a higher rate of low birth weight compared to male neonates, while male neonates had higher incidences of NICU admissions, neonatal assisted ventilation, and in-hospital mortality. The Midwest had the highest rates for NICU admissions in NH/PI (254.2 [217.2, 295.2]), neonatal assisted ventilation in American Indian/Alaska Native women (143.8 [133.2, 155.1]), and in-hospital mortality in BA (4.1 [3.7, 4.5]). The South had the highest rate of low birth weight for BA (244.4 [242.9, 246.0]).</div></div><div><h3>Conclusions</h3><div>Significant racial and regional disparities exist in neonatal outcomes among hypertensive women in the US, with BA mothers experiencing the poorest outcomes. Further research is necessary to develop targeted interventions for high-risk populations.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103152"},"PeriodicalIF":3.3000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Problems in Cardiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0146280625001720","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Maternal hypertension, a major pregnancy complication, can adversely affect newborn health. Our study investigated racial/ethnic disparities in neonatal outcomes among hypertensive pregnant women in the US.

Methods

Using data from the CDC WONDER Natality database, we conducted a retrospective cohort study focusing on live births to hypertensive mothers from 2016 to 2022. We calculated rates [95% CI] per 1000 live births for NICU admissions, neonatal assisted ventilation, low birth weight, and in-hospital mortality across racial/ethnic groups and regions.

Results

We analyzed 2,392,664 live births to hypertensive women. In-hospital neonatal mortality rates were highest in Black American women (BA) (3.6 [3.5, 3.8]). Neonatal assisted ventilation rates were highest in Native Hawaiian/Pacific Islander women (NH/PI) (131.8 [123.4, 140.7]) and low birth weight rates were highest in BA (235.1 [233.9, 236.3]). Across all races, female neonates had a higher rate of low birth weight compared to male neonates, while male neonates had higher incidences of NICU admissions, neonatal assisted ventilation, and in-hospital mortality. The Midwest had the highest rates for NICU admissions in NH/PI (254.2 [217.2, 295.2]), neonatal assisted ventilation in American Indian/Alaska Native women (143.8 [133.2, 155.1]), and in-hospital mortality in BA (4.1 [3.7, 4.5]). The South had the highest rate of low birth weight for BA (244.4 [242.9, 246.0]).

Conclusions

Significant racial and regional disparities exist in neonatal outcomes among hypertensive women in the US, with BA mothers experiencing the poorest outcomes. Further research is necessary to develop targeted interventions for high-risk populations.

查看原文本刊更多论文

围产期高血压和不同种族新生儿结局：2016-2022

背景：孕妇高血压是一种主要的妊娠并发症，可对新生儿健康产生不利影响。我们的研究调查了美国高血压孕妇新生儿结局的种族/民族差异。方法利用美国疾病控制与预防中心WONDER Natality数据库的数据，对2016年至2022年高血压母亲的活产进行回顾性队列研究。我们计算了不同种族/民族和地区新生儿重症监护病房入院率、新生儿辅助通气率、低出生体重率和住院死亡率每1000例活产的95% CI。结果我们分析了2392664例高血压妇女的活产。住院新生儿死亡率最高的是美国黑人妇女（BA）（3.6[3.5, 3.8]）。新生儿辅助通气率最高的是夏威夷原住民/太平洋岛民妇女（NH/PI）（131.8[123.4, 140.7]），低出生体重率最高的是BA（235.1[233.9, 236.3]）。在所有种族中，与男性新生儿相比，女性新生儿的低出生体重率更高，而男性新生儿的NICU入院率、新生儿辅助通气率和住院死亡率更高。中西部地区新生儿重症监护病房住院率最高的是NH/PI(254.2[217.2, 295.2])，新生儿辅助通气的美国印第安/阿拉斯加原住民妇女（143.8 [133.2,155.1]），BA的住院死亡率最高（4.1[3.7,4.5]）。南方地区BA低出生体重率最高（244.4[242.9,246.0]）。结论：美国高血压妇女的新生儿结局存在明显的种族和地区差异，BA母亲的结局最差。需要进一步的研究来制定针对高危人群的有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.