Study of nanohydroxyapatite composites loaded with gentamicin sulfate and silver nanoparticles

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-08-20 DOI:10.1016/j.jmbbm.2025.107172

Klaudia Malisz , Beata Świeczko – Żurek , Jakub Karczewski , Aleksandra Mirowska , Anna Pałubicka

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Abstract

The aim of the work is to compare the properties of nanohydroxyapatite coatings containing antibiotic - gentamicin or silver nanoparticles. The coatings were obtained using the electrophoretic deposition method (EDP). The additives were introduced by the immersion method. Evaluation of the coating was performed by using a Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectrometer (EDX), and a drop shape analyzer. Antibacterial properties were examined by assessing the surface after incubation in a bacterial solution for 30 days. The corrosion properties of the materials were also assessed. Silver nanoparticles and the antibiotic were successfully incorporated into the nanohydroxyapatite coating. The wettability test shows the hydrophilic behavior of the coatings that contains an antibiotic. Furthermore, the average contact angle (CA) value for nanohydroxyapatite doped with silver nanoparticles increased to 120°. The highest surface roughness was observed for the coating containing silver. All nanohydroxapatite modifications improved the corrosion resistance of the titanium alloy, but the best results were obtained by nanohydroxapatite with AgNPs, where the Icorr parameter was 15.5 ± 3.9 μA/cm², Ecorr showed the most positive value of 25.6 ± 1.7 mV, and Rpol was 8.1 ± 0.2 kΩ cm². For comparison, the corresponding values for the nHAp coating are: 41.7 ± 1.9 μA/cm², -56.1 ± 1.6 mV, 3.6 ± 0.4 kΩ cm². It was found that both the coating with added AgNPs and the one with a higher concentration of gentamicin exhibited antibacterial properties. It can be stated that the silver-containing coating shows greater potential for combating perioperative infections due to the combination of good corrosion resistance and broad-spectrum antibacterial properties.

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纳米羟基磷灰石复合材料负载硫酸庆大霉素和纳米银的研究

这项工作的目的是比较纳米羟基磷灰石涂层含有抗生素庆大霉素或银纳米颗粒的性能。涂层采用电泳沉积法（EDP）制备。采用浸渍法引入添加剂。利用扫描电子显微镜（SEM）、能量色散x射线光谱仪（EDX）和液滴形状分析仪对涂层进行了评价。在细菌溶液中孵育30天后，通过评估表面来检查抗菌性能。并对材料的腐蚀性能进行了评价。银纳米粒子和抗生素成功地结合到纳米羟基磷灰石涂层中。润湿性测试显示了含有抗生素的涂层的亲水性。此外，掺银纳米粒子的纳米羟基磷灰石的平均接触角（CA）值增加到120°。观察到含银涂层的表面粗糙度最高。所有纳米羟基磷灰石改性均能提高钛合金的耐蚀性，但纳米羟基磷灰石改性AgNPs效果最好，Icorr参数为15.5±3.9 μA/cm2， Ecorr值为25.6±1.7 mV， Rpol值为8.1±0.2 kΩ cm2。相比之下，nHAp涂层的对应值分别为：41.7±1.9 μA/cm2, -56.1±1.6 mV, 3.6±0.4 kΩ cm2。结果表明，添加AgNPs的涂层和添加庆大霉素的涂层均具有抗菌性能。可以说，由于良好的耐腐蚀性和广谱抗菌性能的结合，含银涂层显示出更大的抗围手术期感染的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.