Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population

IF 3 2区农林科学 Q2 INFECTIOUS DISEASES

Transboundary and Emerging Diseases Pub Date : 2025-08-25 DOI:10.1155/tbed/5779652

Liangliang Wu, Likuan Zhang, Xiaoqi Wang, Wei Huang, Stefan Schwarz, Andrea Brenciani, Chenglong Li, Xiang-Dang Du

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Abstract

Streptococcus suis is an important zoonotic pathogen that can cause severe infections in both humans and pigs. The prevalence of S. suis serotype 14 in sporadic cases in China has been gradually increasing during recent years. However, the current understanding of S. suis serotype 14 is limited. In this study, we investigated the population structure, phylogenetic relationships, antimicrobial resistance, and pathogenicity of 125 S. suis serotype 14 strains. These strains clustered into 12 sequence types (STs) and three clonal complexes (CCs), with ST7 accounting for the highest proportion (73.6%), which indicates significant pathogenic potential, given that ST1 and ST7 are well-known high-virulence STs in S. suis. Bioinformatic analysis showed that all serotype 14 strains carry the virulence genes sly and epf, while 74.4% of the strains carry the virulence gene mrp. In the pathogenicity test (n = 5), the human strain Ss2301, Ss2401, and the porcine strain L966, SC42 proved to be highly virulent strains. These data highlight the virulence potential of serotype 14 S. suis. Tetracycline resistance genes and macrolide, lincosamide, and streptogramin B (MLS_B) resistance genes were most frequently detected in the population. The transmission of the former genes mainly depends on integrative and conjugative elements (ICEs), while the latter depends on both ICEs and prophages. This study not only confirmed the pathogenic potential of serotype 14 S. suis but also provided valuable information for improving prevention and control strategies for S. suis infections.

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猪链球菌血清14型：一个不可忽视的人畜共患群体

猪链球菌是一种重要的人畜共患病原体，可引起人类和猪的严重感染。近年来，中国散发病例中猪链球菌血清14型的流行率逐渐上升。然而，目前对猪链球菌血清型14的了解有限。本研究对125株猪链球菌14型的种群结构、系统发育关系、耐药性和致病性进行了研究。这些菌株聚集成12个序列型（STs）和3个克隆复合物（CCs），其中ST7所占比例最高（73.6%），考虑到ST1和ST7是猪链球菌中众所周知的高毒力STs，这表明具有显著的致病潜力。生物信息学分析显示，14血清型菌株全部携带毒力基因sly和epf， 74.4%的菌株携带毒力基因mrp。在致病性试验（n = 5）中，人株Ss2301、Ss2401和猪株L966、SC42被证明是高毒力菌株。这些数据突出了血清型14猪链球菌的潜在毒力。人群中最常见的是四环素耐药基因和大环内酯类、利可沙胺类和链状gramin B （MLSB）耐药基因。前者基因的传递主要依赖于整合结合元件（integrative and conjuative elements, ICEs），后者则同时依赖于整合结合元件和噬菌体。本研究不仅证实了血清14型猪链球菌的致病潜力，而且为改进猪链球菌感染的预防和控制策略提供了有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.