Front Cover: Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma (ChemBioChem 15/2025)

IF 2.8 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
ChemBioChem Pub Date : 2025-08-25 DOI:10.1002/cbic.70013
Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea-Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira, Wolfgang Link
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引用次数: 0

Abstract

The cover image illustrates the inhibition of the nuclear export receptor CRM1 by a small molecule inhibitor (in red) that covalently binds to cysteine at position 528. CRM1, a ring-shaped protein, is overexpressed in several human cancers, including glioblastoma (GBM). Its inhibition can disrupt three key oncogenic signaling pathways that drive GBM progression. CRM1 facilitates the nuclear export of proteins containing a nuclear export signal through the nuclear pore complex (depicted in yellow), which is embedded in the nuclear envelope, from the nucleus to the cytoplasm. More details can be found in the article 10.1002/cbic.202500195 by Wolfgang Link and co-workers.

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封面:染色质衍生物作为靶向胶质母细胞瘤的CRM1抑制剂(ChemBioChem 15/2025)
封面图片显示了一种小分子抑制剂(红色)对核输出受体CRM1的抑制作用,这种抑制剂在528位与半胱氨酸共价结合。CRM1是一种环状蛋白,在包括胶质母细胞瘤(GBM)在内的几种人类癌症中过度表达。它的抑制作用可以破坏驱动GBM进展的三个关键致癌信号通路。CRM1促进含有核输出信号的蛋白质通过嵌入在核膜中的核孔复合体(黄色部分)从细胞核向细胞质输出核。更多细节可以在10.1002/cbic文章中找到。202500195作者:Wolfgang Link和同事。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemBioChem
ChemBioChem 生物-生化与分子生物学
CiteScore
6.10
自引率
3.10%
发文量
407
审稿时长
1 months
期刊介绍: ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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