Prevalence of Erectile Dysfunction in Malagasy Patients With Diabetes Mellitus and Its Associations With Atherosclerotic Cardiovascular Diseases: A Cross-Sectional Study

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM

Endocrinology, Diabetes and Metabolism Pub Date : 2025-08-25 DOI:10.1002/edm2.70098

Sitraka Angelo Raharinavalona, Tafitarilova Dorland Ranjandriarison, Thierry Razanamparany, Romuald Randriamahavonjy, Andrianirina Dave Patrick Rakotomalala

{"title":"Prevalence of Erectile Dysfunction in Malagasy Patients With Diabetes Mellitus and Its Associations With Atherosclerotic Cardiovascular Diseases: A Cross-Sectional Study","authors":"Sitraka Angelo Raharinavalona, Tafitarilova Dorland Ranjandriarison, Thierry Razanamparany, Romuald Randriamahavonjy, Andrianirina Dave Patrick Rakotomalala","doi":"10.1002/edm2.70098","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Our study aims to determine the prevalence of erectile dysfunction (ED) and its associations with atherosclerotic cardiovascular disease (ASCVD) in Malagasy patients with diabetes mellitus (DM).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cross-sectional study was conducted over a period of 3 years at the Soavinandriana Hospital Center. Erectile function was assessed using the International Index of Erectile Function 5-item version (IIEF-5) questionnaire, with a score of less than 22 indicating ED. The presence of ASCVD was confirmed in cases where carotid atherosclerosis (CAS), lower limb arteriopathy (LLA), coronary heart disease (CHD) and/or ischaemic stroke were present.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The study population included 305 patients diagnosed with diabetes mellitus (DM). The prevalence of erectile dysfunction (ED) was 73.4%. According to the bivariate analysis, the risk factors for ED were age ≥ 55 years (odds ratio [OR] 12.0 (6.34–23.4)), hypertension (OR 6.02 (3.27–11.3)), physical inactivity (OR 8.86 (4.85–16.6)), smoking (OR 2.53 (1.32–5.09)), dyslipidemia (OR 4.11 (2.33–7.32)), type 2 DM (OR 8.80 (1.53–91.0)) and diabetes duration ≥ 10 years (OR 2.24 (1.11–4.87)), renin-angiotensin-aldosterone system blockers (OR 6.27 (3.43–11.6)), calcium-channel blockers (OR 3.01 (1.69–5.48)), diuretics (OR 2.14 (1.06–4.66)) and beta-blockers (OR 4.55 (1.85–13.5)). After adjusting for age, hypertension, physical inactivity, smoking and dyslipidemia, ED was significantly associated with ASCVD (OR 1.88 (1.01–3.69)), and CAS (OR 1.89 (1.03–3.22)). Adjusting for age, type and duration of DM, ED was found to be significantly associated with ASCVD (OR 1.91 (1.01–3.58)) and CAS (OR 2.31 (1.11–4.85)). However, there was no statistically significant association between ED, LLA, CHD and ischaemic stroke.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ED was very common and may be a predictor of ASCVD in patients with DM, particularly CAS. Consequently, the presence of ED should prompt the search for ASCVD, and vice versa.</p>\n </section>\n </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 5","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70098","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, Diabetes and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/edm2.70098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

Our study aims to determine the prevalence of erectile dysfunction (ED) and its associations with atherosclerotic cardiovascular disease (ASCVD) in Malagasy patients with diabetes mellitus (DM).

Methods

This cross-sectional study was conducted over a period of 3 years at the Soavinandriana Hospital Center. Erectile function was assessed using the International Index of Erectile Function 5-item version (IIEF-5) questionnaire, with a score of less than 22 indicating ED. The presence of ASCVD was confirmed in cases where carotid atherosclerosis (CAS), lower limb arteriopathy (LLA), coronary heart disease (CHD) and/or ischaemic stroke were present.

Results

The study population included 305 patients diagnosed with diabetes mellitus (DM). The prevalence of erectile dysfunction (ED) was 73.4%. According to the bivariate analysis, the risk factors for ED were age ≥ 55 years (odds ratio [OR] 12.0 (6.34–23.4)), hypertension (OR 6.02 (3.27–11.3)), physical inactivity (OR 8.86 (4.85–16.6)), smoking (OR 2.53 (1.32–5.09)), dyslipidemia (OR 4.11 (2.33–7.32)), type 2 DM (OR 8.80 (1.53–91.0)) and diabetes duration ≥ 10 years (OR 2.24 (1.11–4.87)), renin-angiotensin-aldosterone system blockers (OR 6.27 (3.43–11.6)), calcium-channel blockers (OR 3.01 (1.69–5.48)), diuretics (OR 2.14 (1.06–4.66)) and beta-blockers (OR 4.55 (1.85–13.5)). After adjusting for age, hypertension, physical inactivity, smoking and dyslipidemia, ED was significantly associated with ASCVD (OR 1.88 (1.01–3.69)), and CAS (OR 1.89 (1.03–3.22)). Adjusting for age, type and duration of DM, ED was found to be significantly associated with ASCVD (OR 1.91 (1.01–3.58)) and CAS (OR 2.31 (1.11–4.85)). However, there was no statistically significant association between ED, LLA, CHD and ischaemic stroke.

Conclusion

ED was very common and may be a predictor of ASCVD in patients with DM, particularly CAS. Consequently, the presence of ED should prompt the search for ASCVD, and vice versa.

Abstract Image

查看原文本刊更多论文

马达加斯加糖尿病患者勃起功能障碍患病率及其与动脉粥样硬化性心血管疾病的关系：一项横断面研究

本研究旨在确定马达加斯加糖尿病（DM）患者的勃起功能障碍（ED）患病率及其与动脉粥样硬化性心血管疾病（ASCVD）的关系。方法在Soavinandriana医院中心进行了为期3年的横断面研究。使用国际勃起功能指数5项版（IIEF-5）问卷评估勃起功能，得分低于22表示ED。在存在颈动脉粥样硬化（CAS）、下肢动脉病变（LLA）、冠心病（CHD）和/或缺血性卒中的病例中确认ASCVD的存在。结果纳入305例糖尿病（DM）患者。勃起功能障碍（ED）患病率为73.4%。根据双因素分析，ED的危险因素为年龄≥55岁（比值比为12.0(6.34-23.4)）、高血压（比值比为6.02(3.27-11.3)）、缺乏运动（比值比为8.86(4.85-16.6)）、吸烟（比值比为2.53(1.32-5.09)）、血脂异常（比值比为4.11(2.33-7.32)）、2型糖尿病（比值比为8.80(1.53-91.0)）、糖尿病病程≥10年（比值比为2.24(1.11-4.87)）、肾素-血管紧张素-醛固酮系统阻滞剂（比值比为6.27(3.43-11.6)）、钙通道阻滞剂（比值比为3.01(1.69-5.48)）、利尿剂（OR 2.14(1.06-4.66)）和受体阻滞剂（OR 4.55(1.85-13.5)）。在调整了年龄、高血压、缺乏运动、吸烟和血脂异常等因素后，ED与ASCVD （OR 1.88(1.01-3.69)）和CAS （OR 1.89(1.03-3.22)）显著相关。调整DM的年龄、类型和病程后，发现ED与ASCVD （OR 1.91(1.01-3.58)）和CAS （OR 2.31(1.11-4.85)）显著相关。然而，ED、LLA、CHD与缺血性脑卒中之间无统计学意义的相关性。结论ED非常常见，可能是糖尿病患者ASCVD的预测因子，尤其是CAS患者。因此，ED的存在应该提示寻找ASCVD，反之亦然。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊