Clinical recommendations for the management of Pythium insidiosum keratitis

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface Pub Date : 2025-08-18 DOI:10.1016/j.jtos.2025.08.003

Bhupesh Bagga , Lakshminarayanan Gowtham , Ali R. Djalilian , Savitri Sharma

引用次数: 0

Abstract

Pythium insidiosum has emerged as a challenging cause of keratitis in recent decades, due to its unique microbiological and clinical features, often is mistaken for fungal keratitis. Anti-fungal therapies have proven ineffective due to the organism's distinct cellular structure. Based on in vitro and in vivo models there has been a shift towards the use of antibacterial agents like linezolid and azithromycin, which have shown promising results. This concise review provides an update on the recommended diagnostic techniques and management strategies to assist clinicians in navigating this complex disease landscape.

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治疗藏皮角膜炎的临床建议

近几十年来，由于其独特的微生物学和临床特征，二氧化钛已成为角膜炎的一个具有挑战性的原因，经常被误认为是真菌性角膜炎。抗真菌疗法已被证明无效，由于生物体的独特的细胞结构。在体外和体内模型的基础上，已经转向使用抗菌药物，如利奈唑胺和阿奇霉素，这些药物已经显示出有希望的结果。这篇简明的综述提供了最新的推荐诊断技术和管理策略，以帮助临床医生在这种复杂的疾病景观中导航。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Surface 医学-眼科学

CiteScore

11.60

自引率

14.10%

发文量

审稿时长

39 days

期刊介绍： The Ocular Surface, a quarterly, a peer-reviewed journal, is an authoritative resource that integrates and interprets major findings in diverse fields related to the ocular surface, including ophthalmology, optometry, genetics, molecular biology, pharmacology, immunology, infectious disease, and epidemiology. Its critical review articles cover the most current knowledge on medical and surgical management of ocular surface pathology, new understandings of ocular surface physiology, the meaning of recent discoveries on how the ocular surface responds to injury and disease, and updates on drug and device development. The journal also publishes select original research reports and articles describing cutting-edge techniques and technology in the field. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center