A large π-conjugated organic photothermal agent for photoacoustic-guided photothermal therapy

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-08-23 DOI:10.1016/j.dyepig.2025.113166

Lihan Chen , Huihui Liang , Pei Wang , Huiyu Si , Youhui Zhang , Xin Lai , Honglong Zou , Kexin Zhou , Guodong Xu , Yonggui Song , Xin Zhou , Xunfan Liao

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引用次数: 0

Abstract

Multimodal imaging-guided combinational phototherapies triggered by a single near-infrared (NIR) photothermal agent are promising approach for the treatment of breast cancer. However, the bottleneck is lack of stable photothermal materials with NIR absorption and high photothermal conversion efficiency (PCE). Herein, we have developed a novel π-conjugated skeleton organic photothermal agent (DTPC-DFIC) with strong NIR absorption in the region from 770 to 1000 nm. The nanoparticles of DTPC-DFIC (DTPC-DFIC NPs) encapsulated with amphiphilic DSPE-mPEG2000 by nanoprecipitation method, can be used for photoacoustic imaging-guided photothermal therapy (PTT). Notably, DTPC-DFIC NPs shown good biocompatibility, photostability and a high photothermal conversion efficiency up to 72.3 %. In vivo and in vitro experiments confirmed that the DTPC-DFIC NPs have an excellent biosafety and an efficient anti-tumor effect. Overall, this work not only proposes a promising large π-conjugated skeleton organic photothermal agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

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一种用于光声引导光热治疗的大π共轭有机光热剂

由单一近红外（NIR）光热剂触发的多模态成像引导组合光疗法是治疗乳腺癌的一种很有前途的方法。然而，缺乏具有近红外吸收和高光热转换效率（PCE）的稳定光热材料是瓶颈。本文研制了一种新型π共轭骨架型有机光热剂（DTPC-DFIC），在770 ~ 1000 nm范围内具有较强的近红外吸收。采用纳米沉淀法将两亲性DSPE-mPEG2000包封成DTPC-DFIC纳米粒子（DTPC-DFIC NPs），可用于光声成像引导光热治疗（PTT）。值得注意的是，dpc - dfic NPs具有良好的生物相容性、光稳定性和高达72.3%的光热转换效率。体内和体外实验证实，DTPC-DFIC NPs具有良好的生物安全性和有效的抗肿瘤作用。总之，本研究不仅提出了一种有前景的大π共轭骨架有机光热剂，而且为开发高效的纳米肿瘤治疗材料提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.