A pH-responsive multimodal antimicrobial nanosystem for plant disease control

IF 4 1区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pesticide Biochemistry and Physiology Pub Date : 2025-08-21 DOI:10.1016/j.pestbp.2025.106651

Aiguo Gu , Chengshuai He , Shuo Zhang , Hao Wu , Song Yang , Jie Zhou , Yunhao Gao

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Abstract

Nanocarrier-based controlled-release technologies significantly enhance the effective utilization rate of pesticides. Multimodal synergistic antimicrobial strategies that disrupt multiple pesticide resistance pathways are considered promising for plant disease management. In this study, a novel pH-responsive pesticide delivery system based on kasugamycin-intercalated ZnFe hydrotalcites (KAS-Zn-Fe HTlc) was developed to achieve synergistic antibacterial effects. KAS-Zn-Fe HTlc was synthesized via a co-precipitation method. Its physicochemical properties were characterized using SEM, XRD, UV–vis, and FT-IR. The loading capacity, controlled release kinetics, thermal stability, photostability, antibacterial activity, and crop safety were evaluated. KAS-Zn-Fe HTlc exhibited rapid release of KAS and Zn²⁺ under acidic conditions. KAS-Zn-Fe HTlc enhanced the thermal stability of KAS and significantly reduced its photodegradation during the initial phase. Bioactivity assays demonstrated that KAS-Zn-Fe HTlc exhibited 32-fold and 2-fold increased antibacterial activity against Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. lachrymans, respectively, when compared to KAS. No phytotoxicity was observed in tomato seedlings treated with KAS-Zn-Fe HTlc. Therefore, KAS-Zn-Fe HTlc holds significant potential for synergistic antimicrobial functions and offers a sustainable approach to plant disease control.

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植物病害控制的ph响应多模态抗菌纳米系统

纳米载体控释技术可显著提高农药的有效利用率。破坏多种农药抗性途径的多模式协同抗菌策略被认为是植物病害管理的有希望的。本研究开发了一种基于卡苏霉素插层ZnFe水滑石（KAS-Zn-Fe HTlc）的ph响应型农药给药体系，以达到协同抗菌效果。采用共沉淀法合成了KAS-Zn-Fe HTlc。采用SEM、XRD、UV-vis和FT-IR对其理化性质进行了表征。对其负载能力、控释动力学、热稳定性、光稳定性、抗菌活性和作物安全性进行了评价。在酸性条件下，KAS- zn - fe HTlc表现出KAS和Zn2+的快速释放。KAS- zn - fe HTlc增强了KAS的热稳定性，显著降低了KAS初始阶段的光降解。生物活性实验表明，KAS-Zn-Fe HTlc对密歇根克拉维杆菌的抑菌活性分别提高32倍和2倍。密歇根菌和丁香假单胞菌。与KAS相比，分别是泪人。经KAS-Zn-Fe HTlc处理的番茄幼苗未见植物毒性。因此，KAS-Zn-Fe HTlc具有显著的协同抗菌功能潜力，并为植物病害控制提供了可持续的途径。

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来源期刊

Pesticide Biochemistry and Physiology 生物-昆虫学

CiteScore

7.00

自引率

8.50%

发文量

238

审稿时长

4.2 months

期刊介绍： Pesticide Biochemistry and Physiology publishes original scientific articles pertaining to the mode of action of plant protection agents such as insecticides, fungicides, herbicides, and similar compounds, including nonlethal pest control agents, biosynthesis of pheromones, hormones, and plant resistance agents. Manuscripts may include a biochemical, physiological, or molecular study for an understanding of comparative toxicology or selective toxicity of both target and nontarget organisms. Particular interest will be given to studies on the molecular biology of pest control, toxicology, and pesticide resistance. Research Areas Emphasized Include the Biochemistry and Physiology of: • Comparative toxicity • Mode of action • Pathophysiology • Plant growth regulators • Resistance • Other effects of pesticides on both parasites and hosts.