Response to Commentary on “Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study”

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Lei Xi, Juan Shi, Ying Peng, Yifei Zhang, Yanan Cao, Weiqing Wang
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引用次数: 0

Abstract

We thank the authors for their insightful comments and for recognizing that our manuscript provides valuable details about behavioral and genetic factors affecting the risk of obesity in people with type 2 diabetes (T2D) [1].

Firstly, as mentioned in our article, there may be recall bias based on patient self-reported sleep duration, and objectively measuring habitual sleep duration using actigraphy can provide more reliable data. However, considering its simplicity, practicality, and correlation with instrument measurement results, patients' self-reported sleep duration is still internationally recognized and widely used in population-based studies [2, 3].

Secondly, the relationship between sleep, diabetes and obesity is really complex and challenging. As mentioned by the authors, most exploratory experiments on sleep are temporary, especially for sleep deprivation. There are interactions among sleep, diabetes and obesity that impact cardiovascular and metabolic health, just like the intertwined trio. To avoid the potential impact of sleep related diseases, we excluded patients who reported implausible values of sleep duration (i.e., < 3 or > 12 h/night), use of sleeping aids, or psychiatric medications at baseline. It should be pointed out that the above efforts cannot completely eliminate the potential impact of sleep disorders on our study results, and how to reduce their potential effects is also one of the key considerations in our future research. The Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) are indeed effective tools.

As we mentioned in the article, we acknowledge that “although we have adjusted for several covariates, there are potential confounders that could influence the results, such as dietary habits, physical activity, socioeconomic biases, and glucose-lowering medications, which we did not include in this study, and further research is needed to strengthen our understanding of these complex associations”, when it comes to both clinical and genetic analysis. In addition, a more complex and precise polygenic risk score (PRS) model for body mass index (BMI) is also under consideration.

In conclusion, we thank the authors for the wise and valuable comments and suggestions. We hope these clarifications address the issues raised and we intend to use more complex and appropriate models to explore their associations in future research.

The authors declare no conflicts of interest.

对《2型糖尿病患者睡眠表型、遗传易感性和肥胖风险:一项全国前瞻性队列研究》评论的回应
我们感谢作者的深刻见解,并承认我们的论文提供了影响2型糖尿病(T2D)患者肥胖风险的行为和遗传因素的有价值的细节。首先,正如我们在文章中提到的,基于患者自我报告的睡眠时间可能存在回忆偏差,使用活动描记仪客观测量习惯性睡眠时间可以提供更可靠的数据。然而,考虑到患者自我报告睡眠时间的简单、实用以及与仪器测量结果的相关性,患者自我报告睡眠时间仍然是国际上公认的,并被广泛应用于基于人群的研究[2,3]。其次,睡眠、糖尿病和肥胖之间的关系非常复杂和具有挑战性。正如作者所提到的,大多数关于睡眠的探索性实验都是暂时的,尤其是对睡眠剥夺的实验。睡眠、糖尿病和肥胖之间存在相互作用,影响心血管和代谢健康,就像交织在一起的三重奏一样。为了避免睡眠相关疾病的潜在影响,我们排除了在基线时报告睡眠持续时间(即每晚3或12小时)、使用助眠剂或精神药物的患者。需要指出的是,上述努力并不能完全消除睡眠障碍对我们研究结果的潜在影响,如何降低其潜在影响也是我们未来研究的重点考虑之一。匹兹堡睡眠质量指数(PSQI)和爱普沃斯嗜睡量表(ESS)确实是有效的工具。正如我们在文章中提到的,我们承认“尽管我们已经调整了几个协变量,但仍有可能影响结果的潜在混杂因素,如饮食习惯、体育活动、社会经济偏见和降糖药物,我们没有将其纳入本研究,需要进一步的研究来加强我们对这些复杂关联的理解”,当涉及到临床和遗传分析时。此外,一种更为复杂和精确的体重指数(BMI)多基因风险评分(PRS)模型也在考虑之中。最后,我们感谢作者提出的明智而宝贵的意见和建议。我们希望这些澄清能解决所提出的问题,我们打算在未来的研究中使用更复杂和合适的模型来探索它们之间的联系。作者声明无利益冲突。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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