Identification of Growth-Related SNPs and Candidate Genes in the Genome of Zig-Zag Eel (Mastacembelus armatus) by GWAS

IF 2.8 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Chong Han, Kaichun Chen, Jiaxing Cui, Mingxiang Cui, Hu Shu
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引用次数: 0

Abstract

The zig-zag eel (Mastacembelus armatus) is an economically important aquaculture species in south China. Currently, the genome-wide association study (GWAS) for growth traits of zig-zag eel was first performed. A total of 175 zig-zag eels were measured for body height (BH), body length (BL), body weight (BW), body thickness (BT), head length (HL), and total length (TL) and genotyped using whole genome resequencing. After quality control, a total of 13,844,114 high-confidence SNPs were detected uniformly across 24 chromosomes. After GWAS, a total of 2, 1, 2, 2, 1, and 2 SNPs were significantly associated with BH, BL, BW, BT, HL, and TL traits, respectively. In addition, many candidate genes surrounding these SNPs have been shown to be closely associated with growth, including ppt1, cap1, lnr, and fgfr2. In all, these results lay a good foundation for exploring the molecular basis of growth regulation and molecular marker-assisted selection.

用GWAS方法鉴定z - zag鳗鱼生长相关snp及候选基因
锯齿鳗(Mastacembelus armatus)是中国南方重要的水产养殖品种。目前,首次开展了锯齿鳗生长性状全基因组关联研究。测定175只之字形鳗体高(BH)、体长(BL)、体重(BW)、体厚(BT)、头长(HL)和全长(TL),并采用全基因组重测序进行基因分型。经过质量控制,共在24条染色体中均匀检测到13,844,114个高置信度snp。GWAS后,共有2个、1个、2个、2个、1个和2个snp分别与BH、BL、BW、BT、HL和TL性状显著相关。此外,许多围绕这些snp的候选基因已被证明与生长密切相关,包括ppt1、cap1、lnr和fgfr2。这些结果为探索生长调控的分子基础和分子标记辅助选择奠定了良好的基础。
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来源期刊
Marine Biotechnology
Marine Biotechnology 工程技术-海洋与淡水生物学
CiteScore
4.80
自引率
3.30%
发文量
95
审稿时长
2 months
期刊介绍: Marine Biotechnology welcomes high-quality research papers presenting novel data on the biotechnology of aquatic organisms. The journal publishes high quality papers in the areas of molecular biology, genomics, proteomics, cell biology, and biochemistry, and particularly encourages submissions of papers related to genome biology such as linkage mapping, large-scale gene discoveries, QTL analysis, physical mapping, and comparative and functional genome analysis. Papers on technological development and marine natural products should demonstrate innovation and novel applications.
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