pH-Dependent Structural Changes in Polyethyleneimine Affect its Gene Transfection Efficiency (Small 33/2025)

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-08-22 DOI:10.1002/smll.70028

Shivalika Sharma, Manjari Mishra, Aswin T Srivatsav, Kamendra P. Sharma, Shobhna Kapoor

引用次数: 0

Abstract

Polyethyleneimine

In article number 2411293, Kamendra P. Sharma, Shobhna Kapoor, and co-workers show that time-dependent self-assembly of polyethyleneimine (PEI) chains conditioned at pH 3.0 leads to hierarchical microstructures that impede its gene transfection. However, PEI, transitioned through pH 1.4, provides efficient transfection. This work highlights how the level of protonation, the subsequent charge density variations and the resultant microstructure of PEI chains facilitates or hinders gene transfection.

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ph依赖性聚乙烯亚胺结构变化影响其基因转染效率（Small 33/2025）

在2411293号文章中，Kamendra P. Sharma， Shobhna Kapoor和同事们表明，pH值为3.0时，聚乙烯亚胺（PEI）链的时间依赖性自组装导致分层微观结构阻碍其基因转染。然而，PEI在pH值为1.4时转移，提供了有效的转染。这项工作强调了质子化水平、随后的电荷密度变化和PEI链的最终微观结构如何促进或阻碍基因转染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

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