Identification of neuro-inflammatory biomarkers through non-invasive advanced neuroimaging techniques in pharmaco-resistant epilepsy: A systematic review

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-08-22 DOI:10.1016/j.yebeh.2025.110641

Dayana Haidar Shoukair , Rania El Majzoub , Mariam Kassem , Ali Ismail , Ghida Safadieh , Jana Kotaich , Elissa El Toum , Mohammad Fayyad-Kazan , Bahia Chahine

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引用次数: 0

Abstract

Objectives

The primary aim is to conduct a comprehensive review focusing on the identification of neuro-inflammatory biomarkers using advanced non-invasive neuroimaging tools in pharmaco-resistant epilepsy.

Methods

A systematic search was conducted through four different databases, namely PubMed, Embase, Web of Science, and Google Scholar. Title and abstract screening, full text assessment, data extraction, and quality evaluation, were performed by two independent reviewers. ARRIVE 2.0 guidelines tool, was used to evaluate the quality of the included studies in this review.

Results

A total of 562 records were generated through literature search. Among these, 12 experimental studies met the eligibility criteria, and were included in the qualitative review. These studies identified the following six neuroinflammatory biomarkers in pharmacoresistant epilepsy: TSPO, BBBD, HMGB1, LRP1, P-gp, and MPO. TSPO was the most frequent identified biomarker by six studies out of 12. Within the included studies, eight use positron emission tomography (PET) as their neuroimaging modality of choice, five employ magnetic resonance imaging (MRI), with one specifically employing an MRI T2 sequence, four utilize single photon emission computed tomography (SPECT), and one study uses computed tomography (CT) imaging technique.

Conclusion

This review identified six neuroinflammatory biomarkers in drug-resistant epilepsy using noninvasive neuroimaging tools. These biomarkers could be used as diagnostic, predictive, and therapeutic targets. Moreover, they can be used to delineate epileptic foci in the presurgical evaluation of refractory epileptic patients. However, these studies are still in the preclinical phase, requiring further research in this field.

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通过非侵入性高级神经成像技术鉴定抗药癫痫的神经炎症生物标志物：系统综述

本研究的主要目的是对利用先进的非侵入性神经成像工具识别抗药癫痫的神经炎症生物标志物进行全面的综述。方法通过PubMed、Embase、Web of Science、b谷歌Scholar 4个数据库进行系统检索。标题和摘要筛选、全文评估、数据提取和质量评估由两名独立审稿人进行。使用ARRIVE 2.0指南工具评价本综述纳入研究的质量。结果通过文献检索共获得562条记录。其中12项实验研究符合入选标准，纳入定性评价。这些研究确定了耐药癫痫中的以下六种神经炎症生物标志物：TSPO、BBBD、HMGB1、LRP1、P-gp和MPO。在12项研究中，有6项研究发现TSPO是最常见的生物标志物。在纳入的研究中，8项使用正电子发射断层扫描（PET）作为其选择的神经成像方式，5项使用磁共振成像（MRI），其中1项专门使用MRI T2序列，4项使用单光子发射计算机断层扫描（SPECT）， 1项研究使用计算机断层扫描（CT）成像技术。结论本综述利用无创神经成像工具鉴定了6种耐药癫痫的神经炎症生物标志物。这些生物标志物可作为诊断、预测和治疗靶点。此外，它们可用于在难治性癫痫患者的术前评估中描绘癫痫病灶。然而，这些研究仍处于临床前阶段，需要在该领域进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.