The association of α-klotho/fibroblast growth factor 23 with cognitive features in euthymic older age patients with bipolar disorder

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-08-21 DOI:10.1016/j.ejpsy.2025.100320

Wen-Yin Chen , Chih Chiang Chiu , Po-Hsiu Kuo , Cho-Yin Huang , Shang-Ying Tsia , Chian-Jue Kuo , Ying-Chih Cheng , Po-Yu Chen , Ming-Chyi Huang

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引用次数: 0

Abstract

Background and objectives

Cognitive aging is common among bipolar disorder (BD). The α-klotho/fibroblast growth factor 23 (FGF23) system has been associated with neuropsychiatric disorders and age-related diseases. This study aimed to investigate α-klotho and FGF23 levels in older-age bipolar disorder (OABD) and examine their associations with aging-related characteristics and cognitive function.

Methods

This study included 87 euthymic OABD, 83 younger-age bipolar disorder (YABD), and 20 healthy controls, to assess α-klotho and FGF23 levels. In OABD group, cognitive function was evaluated using the Brief Assessment of Cognition in Affective Disorders. Aging-related features were assessed, including daily physical activity, grip strength, and the Framingham Risk Score. We examined the correlations between α-klotho/FGF23 levels and aging-related features and explored their associations with cognitive domains in OABD.

Results

The FGF23 levels in OABD were lower compared to those in YABD. The α-klotho levels were not significantly different between three groups. A negative association was observed between FGF23 and global cognitive composite scores (B = -0.006, p = 0.005), particularly in motor speed (B = -0.006, p = 0.001), working memory (B = -0.007, p = 0.006), and verbal fluency (B = -0.002, p = 0.049). Additionally, α-klotho levels were positively associated with working memory (B = 0.735, p = 0.039).

Conclusions

FGF23 had a negative impact on cognitive domains, while α-klotho was positively associated with working memory in OABD. Future research should investigate the dysfunction of the α-klotho/FGF23 axis and incorporate additional validated aging markers in longitudinal studies to confirm the proposed biomarker relationships.

查看原文本刊更多论文

α-klotho/成纤维细胞生长因子23与老年健康双相障碍患者认知特征的关系

背景与目的认知衰老在双相情感障碍（BD）中很常见。α-klotho/成纤维细胞生长因子23 （FGF23）系统与神经精神疾病和年龄相关疾病有关。本研究旨在探讨老年双相情感障碍（OABD）患者α-klotho和FGF23水平，并探讨其与衰老相关特征和认知功能的关系。方法本研究纳入87例正常心境型OABD、83例年轻型双相情感障碍（YABD）和20例健康对照，评估α-klotho和FGF23水平。在OABD组，认知功能评估使用情感障碍认知简要评估。评估了与衰老相关的特征，包括日常体力活动、握力和Framingham风险评分。我们检测了α-klotho/FGF23水平与衰老相关特征的相关性，并探讨了它们与OABD认知领域的关系。结果OABD组FGF23水平低于YABD组。各组间α-klotho水平差异无统计学意义。FGF23与整体认知综合得分呈负相关（B = -0.006, p = 0.005），特别是在运动速度（B = -0.006, p = 0.001）、工作记忆（B = -0.007, p = 0.006）和语言流畅性（B = -0.002, p = 0.049）方面。α-klotho水平与工作记忆呈正相关（B = 0.735, p = 0.039）。结论sfgf23对OABD患者的认知功能域有负向影响，而α-klotho对OABD患者的工作记忆功能域有正向影响。未来的研究应该研究α-klotho/FGF23轴的功能障碍，并在纵向研究中纳入其他经过验证的衰老标志物，以证实所提出的生物标志物关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.