Hydrogen Medicine Materials

IF 14.7 Q1 CHEMISTRY, MULTIDISCIPLINARY
Chao Xia, Lingdong Jiang, Zhaokui Jin and Qianjun He*, 
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引用次数: 0

Abstract

Hydrogen medicine materials are defined as a new concept of biomedical materials specifically engineered to overcome critical challenges in hydrogen medicine, including exploration of biological effects and mechanisms of H2 by in vivo monitoring of H2 transportation, metabolism and transformation, enhancement of H2 therapeutic efficacy against various oxidative stress-related diseases by high-efficiency and site-specific delivery and controlled release of H2, etc. As the smallest and weakly reductive molecule, H2 exhibits some unique biological characteristics, including high tissue permeability, antioxidative stress (OS), anti-inflammation, antiapoptosis, antisenescence, pro-regeneration/pro-self-repairing, anticancer, antibiofilm, high biocompatibility, and biosafety, holding a high value of biomedical applications. However, the related biological mechanisms are not very clear. Typically, multifaceted biological behaviors of H2 in varied pathological microenvironments, such as inflammation, cancer, and injured tissue, have not been well elucidated. Moreover, as a therapeutic agent, the pharmacokinetics of H2, involving absorption, biodistribution, metabolism, and excretion, has to be clarified before clinical application, which needs the development of hydrogen bioprobes to resolve. Based on high biosafety and therapeutic validity of H2, both hydrogen gas inhalator and hydrogen-rich water generator have been clinically approved for adjuvant therapy of some respiratory and digestive system diseases including chronic obstructive pulmonary disease (COPD), hyperuricemia, hyperlipemia, gastrelcosis and coprostasis, but they hardly realize effective delivery toward remote diseased focuses. Therefore, efficient, site-specific and controlled/sustained H2-delivering materials with high biosafety urgently need to be developed for improving the outcome of hydrogen therapy. Based on these unique advantages and unsolved key issues in hydrogen medicine, hydrogen medicine materials as an emerging interdisciplinary field have attracted increasing attention in recent years.

In this Account, we present a brief overview of the recent advances of hydrogen medicine materials including hydrogen bioprobes and hydrogen-delivering materials (hydrogen carriers, hydrolytic hydrogen-generating materials, and catalytic hydrogen-generating materials), as well as their typical biomedical applications including targeted inflammation therapy, targeted tumor therapy, and local tissue repair/regeneration. Finally, a forward-looking perspective on hydrogen medicine materials is demonstrated, which attempts to address the current clinical challenges in the field of hydrogen medicine. Especially, the development of small molecular bioprobes for in vivo H2 detection, the understanding of H2 pharmacokinetics and potential bioeffects, the exploration of the profound mechanisms underlying multifaceted biological behaviors of H2, the development of versatile hydrogen-delivering materials for the treatment of various intractable diseases, and the evaluation of potential long-term toxicity risk of both high-dose H2 and hydrogen-delivering materials are highlighted. This Account is expected to illuminate the way for exploration of hydrogen medicine materials.

Abstract Image

氢医药材料
氢医学材料是为克服氢医学领域的关键挑战而专门设计的生物医学材料的新概念,包括通过体内监测H2的运输、代谢和转化来探索H2的生物学效应和机制,通过H2的高效、位点特异性传递和控制释放来增强H2对各种氧化应激相关疾病的治疗效果等。H2作为最小的弱还原性分子,具有高组织渗透性、抗氧化应激、抗炎症、抗凋亡、抗衰老、促再生/促自我修复、抗癌、抗生物膜、高生物相容性和生物安全性等独特的生物学特性,具有很高的生物医学应用价值。然而,相关的生物学机制尚不清楚。通常,H2在不同病理微环境(如炎症、癌症和损伤组织)中多方面的生物学行为尚未得到很好的阐明。此外,H2作为一种治疗剂,其吸收、生物分布、代谢和排泄等药代动力学在临床应用前还需要明确,这需要氢生物探针的开发来解决。基于氢气的高生物安全性和治疗有效性,氢气吸入器和富氢水发生器已被临床批准用于辅助治疗慢性阻塞性肺疾病(COPD)、高尿酸血症、高脂血症、胃病和前列腺炎等呼吸和消化系统疾病,但难以实现对远处病变病灶的有效输送。因此,迫切需要开发高效、位点特异性、可控制/持续的高生物安全性氢气输送材料,以改善氢气治疗的效果。基于氢医学的这些独特优势和尚未解决的关键问题,氢医学材料作为一个新兴的跨学科领域近年来受到越来越多的关注。在这篇文章中,我们简要概述了氢医学材料的最新进展,包括氢生物探针和氢传递材料(氢载体、水解产氢材料和催化产氢材料),以及它们的典型生物医学应用,包括靶向炎症治疗、靶向肿瘤治疗和局部组织修复/再生。最后,展示了氢医药材料的前瞻性视角,试图解决当前氢医药领域的临床挑战。重点介绍了用于体内H2检测的小分子生物探针的发展,H2药代动力学和潜在生物效应的理解,H2多方面生物学行为的深层机制的探索,用于治疗各种顽固性疾病的多功能氢递送材料的开发,以及大剂量H2和氢递送材料的潜在长期毒性风险评估。本论文有望为氢医药材料的开发指明方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
17.70
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