[Correlation between bone mineral density and bone metabolic markers in preschool children and the influencing factors for bone mineral density].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-08-15 DOI:10.7499/j.issn.1008-8830.2501097

Luopa Ni, Ailipati Tailaiti, Kereman Paerhati, Min-Nan Wang, Yan Guo, Zumureti Yimin, Gulijianati Abulakemu, Rena Maimaiti

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引用次数: 0

Abstract

Objectives: To investigate the correlation between bone mineral density (BMD) and bone metabolic markers in preschool children and the influencing factors for BMD, and to provide a clinical basis for promoting bone health in children.

Methods: A retrospective analysis was performed for the data of 127 preschool children who underwent physical examination in the Department of Child Health Care of the First Affiliated Hospital of Xinjiang Medical University, from June to December 2024. BMD and bone metabolic markers were measured, and physical examination was performed. A multiple linear regression analysis was used to investigate the effect of general information on BMD Z-score in preschool children. Spearman's rank correlation test was used to investigate the correlation of BMD Z-score with 25-hydroxyvitamin D (25-OHD), serum bone Gla protein (BGP), and parathyroid hormone (PTH).

Results: BMD Z-score significantly differed by ethnicity, weight category, and height category (all P<0.05). The multiple linear regression analysis indicated that weight and height significantly influenced BMD Z-score (P<0.05), whereas sex, age, ethnicity, and parental education level did not (P>0.05). In children, BMD Z-score was positively correlated with 25-OHD level (r_s=0.260, P<0.001) and BGP level (r_s=0.075, P=0.025) and was negatively correlated with PTH level (r_s=-0.043, P=0.032).

Conclusions: Weight, height, 25-OHD, BGP, and PTH are influencing factors for BMD in preschool children. In clinical practice, combined measurement of bone metabolic markers may provide a scientific basis for early identification of children with abnormal BMD and prevention of osteoporosis and osteomalacia.

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[学龄前儿童骨密度与骨代谢指标的相关性及骨密度影响因素]。

目的：探讨学龄前儿童骨密度（BMD）与骨代谢指标的相关性及其影响因素，为促进儿童骨骼健康提供临床依据。方法：回顾性分析新疆医科大学第一附属医院儿童保健科于2024年6月至12月对127例学龄前儿童进行体检的资料。测量骨密度和骨代谢指标，并进行体格检查。采用多元线性回归分析探讨一般信息对学龄前儿童BMD Z-score的影响。采用Spearman秩相关检验探讨BMD z评分与25-羟基维生素D （25-OHD）、血清骨玻璃蛋白（BGP）、甲状旁腺激素（PTH）的相关性。结果：BMD Z-score在种族、体重类别和身高类别之间存在显著差异（均为PPP 0.05）。儿童BMD Z-score与25-OHD水平呈正相关（rs=0.260, pr =0.075， P=0.025），与PTH水平呈负相关（rs=-0.043， P=0.032）。结论：体重、身高、25-OHD、BGP、PTH是学龄前儿童骨密度的影响因素。在临床实践中，联合测量骨代谢指标可为早期发现骨密度异常儿童，预防骨质疏松和骨软化症提供科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.