Cutaneous Manifestations in an Infant With Hemophagocytic Lymphohistiocytosis: Case Report.

Abstract

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder characterized by overactivation of the immune system leading to disordered multiorgan inflammation. Allogeneic stem cell transplantation is the required curative treatment of primary HLH. Method: An infant prenatally diagnosed with HLH mutation presented with necrotic cellulitis. Our interdisciplinary team of specialists collaborated to implement early and aggressive supportive wound care strategies, including skin care for high-risk stem cell transplant patients. Results: The patient subsequently underwent allogeneic stem cell transplant with minimal complications and positive outcomes, despite entering the transplant with open skin lesions. Discussion: This complex case highlights the efforts of a multidisciplinary team to partner with the family to provide supportive care to optimize wound healing and improve outcomes.