[Epidemiological and molecular traceability analysis of the first cluster outbreak of D8 genotype measles in Henan Province].

Q3 Medicine

中华预防医学杂志 Pub Date : 2025-08-06 DOI:10.3760/cma.j.cn112150-20250415-00314

X X Zhang, B H Du, D X Feng, W H Wang, J Li, L L Liu, H Zi, Q H Wan, S T Zhao, X L Wang, X B Wu, Y H Guo, Y Y Zhang, D Y Zhao

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Abstract

In February 2025, a local cluster outbreak caused by the D8 genotype Measles virus (MV) was first discovered in Henan Province. Epidemiological investigations and laboratory testing were conducted, including the collection of serum and throat swabs for MV IgM antibody and nucleic acid detection, virus isolation and genetic homology analysis. Measures such as close contact tracing, vaccination rate assessment and supplementary immunization activities were implemented, successfully preventing broader community transmission. A total of three cases were reported during the outbreak, including one imported-related adolescent and two secondary local adult cases. All cases presented with typical symptoms such as fever and rash. Both adult cases were complicated by pneumonia, with one case developing into severe pneumonia. MV genotyping showed that the two secondary cases were both the D8 genotype, with the viral sequences being completely homologous to the Kazakhstan strain. Among the close contacts, 98.2% were adults, and 142 individuals received emergency vaccination.

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河南省首例聚集性暴发D8基因型麻疹流行病学及分子溯源分析

2025年2月，河南省首次发现由D8基因型麻疹病毒（MV）引起的本地聚集性疫情。进行流行病学调查和实验室检测，包括采集血清和咽拭子进行MV IgM抗体和核酸检测、病毒分离和基因同源性分析。采取了密切接触者追踪、疫苗接种率评估和补充免疫活动等措施，成功地防止了更广泛的社区传播。暴发期间共报告了3例病例，包括1例与输入有关的青少年病例和2例继发性当地成人病例。所有病例均有发热、皮疹等典型症状。两例成人病例均合并肺炎，其中1例发展为重症肺炎。MV分型结果显示，2例继发性病例均为D8基因型，病毒序列与哈萨克斯坦株完全同源。在密切接触者中，成人占98.2%，142人接受了紧急预防接种。

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.