Localization and connections of the tail of caudate and caudal putamen in mouse brain.

IF 3 3区 医学 Q2 NEUROSCIENCES
Frontiers in Neural Circuits Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI:10.3389/fncir.2025.1611199
Run-Zhe Ma, Sheng-Qiang Chen, Ge Zhu, Hui-Ru Cai, Jin-Yuan Zhang, Yi-Min Peng, Dian Lian, Song-Lin Ding
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Abstract

The neural circuits of the striatum (caudate and putamen) constitute a crucial component of the extrapyramidal motor system, and dysfunction in these circuits is correlated with significant neurological disorders including Parkinson's disease and Huntington's disease. Many previous studies in rodents revealed the neural connections of the rostral and intermediate parts of the striatum, but relatively fewer studies focused on the caudal striatum, which likely contains both the tail of caudate (CaT) and caudal putamen (PuC). In this study, we investigate the gene markers for the CaT and PuC and brain-wide afferent and efferent projections of the caudal striatum in mice using both anterograde and retrograde neural tracing methods. Some genes such as prodynorphin, otoferlin, and Wolfram syndrome 1 homolog are strongly expressed in CaT and PuC while some others such as neurotensin are almost exclusively expressed in CaT. The major afferent projections of the CaT originate from the substantia nigra (SN), ventral tegmental area, basolateral amygdala, parafascicular nucleus, and visual, somatosensory, auditory and parietal association cortices. The PuC receives its main inputs from the posterior intralaminar nucleus, ventroposterior medial nucleus (VPM), medial geniculate nucleus, and entorhinal, motor and auditory cortices. Both CaT and PuC neurons (including dopamine receptor 1 expressing ones) project in a rough topographical manner to the external and internal divisions of globus pallidus (GP) and SN. However, dopamine receptor 2 expressing neurons in nearly all striatal regions (including CaT and PuC) exclusively target the external GP. In conclusion, the present study has identified the mouse equivalent of the primate CaT and revealed detailed brain-wide connections of the CaT and PuC in rodent. These findings would offer new insights into the functional correlation and disease-related neural circuits related to the caudal striatum.

小鼠脑尾状壳核和尾状壳核尾部的定位和连接。
纹状体(尾状体和壳核)的神经回路构成锥体外运动系统的重要组成部分,这些回路的功能障碍与包括帕金森病和亨廷顿病在内的重大神经系统疾病相关。许多先前的啮齿类动物研究揭示了纹状体吻侧和中间部分的神经连接,但相对较少的研究集中在尾侧纹状体上,尾侧纹状体可能同时包含尾状尾(CaT)和尾侧壳核(PuC)。在这项研究中,我们使用顺行和逆行神经追踪方法研究了小鼠尾侧纹状体的CaT和PuC基因标记以及全脑传入和输出投射。一些基因如prodynorphin、otoferlin和Wolfram综合征1同源基因在CaT和PuC中强烈表达,而另一些基因如神经紧张素几乎只在CaT中表达。CaT的主要传入投射来自黑质(SN)、腹侧被盖区、基底外侧杏仁核、束状旁核以及视觉、体感、听觉和顶叶联合皮层。PuC的主要输入来自板间后核、腹后内侧核(VPM)、内侧膝状核以及内嗅、运动和听觉皮层。CaT和PuC神经元(包括表达多巴胺受体1的神经元)都以粗略的地形方式投射到苍白球(GP)和SN的内外分裂。然而,在几乎所有纹状体区域(包括CaT和PuC)表达多巴胺受体2的神经元只针对外部GP。综上所述,本研究已经确定了与灵长类动物CaT等同的小鼠,并揭示了啮齿动物CaT和PuC在全脑范围内的详细联系。这些发现将为研究与尾状体相关的功能相关性和与疾病相关的神经回路提供新的见解。
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来源期刊
CiteScore
6.00
自引率
5.70%
发文量
135
审稿时长
4-8 weeks
期刊介绍: Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.
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