The management outcomes of chronic subdural hematoma in HIV-Infected individuals.

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Kuzolunga Xulu, Nomusa Shezi, Basil Enicker
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Abstract

Background: Chronic subdural hematoma (CSDH) typically affects the elderly and is associated with significant morbidity and mortality. However, data on its presentation and outcomes in individuals living with HIV are limited. The purpose of the study was to describe the clinical profile and management outcomes of CSDH in HIV-infected patients.

Methods: A retrospective review was conducted between January 2006 and December 2022. Patients were stratified into two groups based on CD4 count ≥ and < 200 cells/µL. Variables analyzed included demographics, clinical characteristics, anti-retroviral therapy (ART) status, radiological findings, surgical management and outcomes.

Results: Forty-eight patients were included, with a median age of 38 years. The majority (52.1%) had a CD4 count ≥ 200 cells/µL. Males comprised 50% of the cohort, with a higher proportion of males in the CD4 count ≥ 200 group (p = 0.029). The median admission Glasgow Coma Scale (GCS) was 14. Common clinical presentations included headaches (47.9%) and hemiparesis (43.8%). ART coverage was 58.3%, and bilateral CSDH was diagnosed in 25%. Most patients (72.9%) received two burr holes. Postoperative complications included recurrence (16.7%), septicemia (10.4%), and subdural empyema (2.1%). Mortality rate was 14.6%. Factors significantly associated with mortality included low GCS, INR > 1.2 and septicemia.

Conclusions: CSDH in HIV-infected individuals presents at a younger age than in the general population. While most patients had CD4 count of ≥ 200 cells/µL, CD4 level was not a predictor of surgical outcome. Mortality was associated with low GCS, increased INR, and septicemia.

Abstract Image

Abstract Image

Abstract Image

hiv感染者慢性硬膜下血肿的治疗结果
背景:慢性硬膜下血肿(CSDH)通常影响老年人,并与显著的发病率和死亡率相关。然而,关于其在艾滋病毒感染者中的表现和结果的数据有限。该研究的目的是描述hiv感染患者的CSDH的临床概况和管理结果。方法:对2006年1月至2022年12月进行回顾性分析。结果:纳入48例患者,中位年龄38岁。大多数(52.1%)CD4计数≥200个细胞/µL。男性占队列的50%,CD4计数≥200组男性比例更高(p = 0.029)。入院格拉斯哥昏迷评分(GCS)中位数为14。常见的临床表现包括头痛(47.9%)和偏瘫(43.8%)。ART覆盖率为58.3%,双侧CSDH诊断率为25%。大多数患者(72.9%)接受2个钻孔。术后并发症包括复发(16.7%)、败血症(10.4%)和硬膜下脓肿(2.1%)。死亡率为14.6%。与死亡率显著相关的因素包括低GCS、INR bbb1.2和败血症。结论:CSDH在hiv感染者中比在一般人群中出现在更年轻的年龄。虽然大多数患者CD4计数≥200细胞/µL,但CD4水平不是手术结果的预测因子。死亡率与低GCS、INR升高和败血症有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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