Rapid radiographic progression in rheumatoid arthritis: Definition, prediction and treatment

IF 8.3 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-08-18 DOI:10.1016/j.autrev.2025.103913

Bo Lv , Fanshu Li , Fanlei Hu , Liling Xu

引用次数: 0

Abstract

Rapid radiographic progression (RRP) in rheumatoid arthritis (RA) is strongly correlated with unfavorable long-term prognostic outcomes. Early identification of RRP is paramount, as prompt intervention and the implementation of intensified therapeutic regimens have the potential to substantially improve clinical outcomes. This review summarized the different definitions and current key predictors of RRP, such as genetic predispositions, body mass index and so on. Furthermore, the existing matrix-based predictive models for RRP were compared. In addition, the potential treatment options for patients with RRP were also outlined. The objective of this review is to improve the early detection of RRP, thereby facilitating timely intervention and the adoption of personalized treatment paradigms that optimize patient prognosis.

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类风湿关节炎的快速影像学进展：定义、预测和治疗。

类风湿关节炎（RA）的放射学快速进展（RRP）与不良的长期预后密切相关。早期识别RRP是至关重要的，因为及时干预和强化治疗方案的实施有可能大大改善临床结果。本文综述了RRP的不同定义和目前的主要预测因素，如遗传易感性、体重指数等。并对现有的基于矩阵的RRP预测模型进行了比较。此外，还概述了RRP患者的潜在治疗方案。本综述的目的是提高RRP的早期发现，从而促进及时干预和采用个性化治疗模式，优化患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.