Formation of Plant Derived Bioactive Peptides During Simulated Gastro-Intestinal Digestion: A Systematic Review

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2025-08-21 DOI:10.1002/biof.70043
Stefania Iametti, Alessandra Bordoni, Mattia Di Nunzio
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Abstract

A plant-based diet is known to be nutrient-dense and rich in fibers, healthy fats, proteins, vitamins, and minerals. A diet rich in plant-based foods may help reduce the risk of chronic diseases such as cardiovascular disease and diabetes. As consumers become more health conscious, there is a growing interest in plant-based diets. In addition to providing essential nutrients, some food proteins may provide additional health benefits, as plant proteins are broken down into bioactive peptides during gastrointestinal digestion, often in dependence on previous processing. Bioactive peptides have several important functions in the body, including antioxidant, antimicrobial, immunomodulatory, and anti-hypertensive effects. To date, several reviews have provided an overview of the generation of bioactive peptides and their associated biological activities and putative health benefits in a range of animal-based foods, but information on plant-based foods is fragmented. We then systematically reviewed the existing literature reporting the release of bioactive peptides from plant-based food products and ingredients after in vitro digestion according to the INFOGEST protocol. The results reported in this review highlight that most of the bioactive peptides of plant origin exhibited antioxidant, anti-hypertensive, and anti-diabetic activity. The relationship between the structure and functionality of peptides and the major gaps in bioactive peptide research were also discussed, to focus on these aspects in future research. This may lead to a better understanding of the behavior of plant proteins in the human gastrointestinal tract, enhancing their contribution as sources of bioactive peptides.

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模拟胃肠道消化过程中植物源性生物活性肽的形成:系统综述
众所周知,植物性饮食营养丰富,富含纤维、健康脂肪、蛋白质、维生素和矿物质。富含植物性食物的饮食可能有助于降低患心血管疾病和糖尿病等慢性疾病的风险。随着消费者越来越注重健康,人们对植物性饮食的兴趣也越来越大。除了提供必需的营养物质外,一些食物蛋白质还可能提供额外的健康益处,因为植物蛋白在胃肠道消化过程中被分解成生物活性肽,通常依赖于先前的加工。生物活性肽在机体中具有多种重要功能,包括抗氧化、抗菌、免疫调节和抗高血压作用。迄今为止,已有几篇综述概述了一系列动物性食品中生物活性肽的产生及其相关的生物活性和假定的健康益处,但关于植物性食品的信息是碎片化的。然后,我们系统地回顾了现有的文献报道,根据INFOGEST协议,植物性食品和成分在体外消化后释放生物活性肽。这篇综述强调了大多数植物源生物活性肽具有抗氧化、抗高血压和抗糖尿病的活性。讨论了肽的结构与功能之间的关系以及生物活性肽研究的主要空白,以期在今后的研究中重点关注这些方面。这可能会导致更好地了解植物蛋白在人类胃肠道中的行为,增强它们作为生物活性肽来源的贡献。
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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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