Effects of the Addition of Aminosilane-Functionalized Titanate Nanotubes in Carboxymethylcellulose-Based Film for Biomedical Applications

IF 3.4 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-08-21 DOI:10.1002/jbm.b.35644

Letícia Terumi Kito, Angélica Galvão Santos Silva, Caroline Machado Andrade Ramos, Diego Morais da Silva, Evelyn Alves Nunes Simonetti, Dayane Batista Tada, Tiago Moreira Bastos Campos, Gilmar Patrocínio Thim

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Abstract

Skin injuries occur when cellular integrity is compromised due to mechanical, physical, or metabolic factors. This study reported on a carboxymethylcellulose (CMC)-based film incorporating TiNT, aiming at its application as a wound dressing. As a minimally invasive approach, titanate nanotubes (TiNT) have been studied due to their photocatalytic properties, biocompatibility, large pore volume, and high surface area. Functionalization with aminosilane groups, using the biological responses of nitrogen, has been explored to enhance cellular interaction. Upon exposure to UV radiation, the dressing releases nanotubes, protecting the lesion from external pathogens and promoting healing. TiNTs were synthesized via a hydrothermal method and 0.2% (v/v) functionalized using 3-aminopropyltrimethoxysilane (APTMS). The films were prepared with 1 (wt%) TiNT or TiNT_NH2 in a 2 (wt%) CMC solution and dried at 60°C for 24 h. Results showed enhanced thermal stability and the potential for controlled nanoparticle release under UV light, with no cytotoxic effects observed. The films demonstrated excellent biocompatibility, making them promising candidates for medical applications.

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氨基硅烷功能化钛酸盐纳米管在羧甲基纤维素基生物医学薄膜中的应用

当细胞完整性由于机械、物理或代谢因素而受损时，就会发生皮肤损伤。本研究报道了一种含有TiNT的羧甲基纤维素（CMC）基薄膜，旨在将其作为伤口敷料。钛酸盐纳米管（TiNT）作为一种微创方法，因其光催化性能、生物相容性、大孔体积和高表面积而受到广泛研究。利用氮的生物反应，氨基硅烷基团功能化已被探索以增强细胞相互作用。暴露在紫外线辐射下，敷料释放纳米管，保护病变免受外部病原体的侵害，促进愈合。采用水热法合成TiNTs，并采用0.2% （v/v）的3-氨基丙基三甲氧基硅烷（APTMS）进行功能化。用1 （wt%）的TiNT或2 （wt%）的TiNT_NH2在2 （wt%）的CMC溶液中制备膜，并在60℃下干燥24 h。结果表明，在紫外光下，纳米颗粒的热稳定性增强，释放可控，没有细胞毒性作用。该薄膜表现出良好的生物相容性，使其成为医学应用的有希望的候选者。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.