Prospective Questionnaire Survey on Adherence to Oral 5-Aminosalicylic Acid in Patients With Ulcerative Colitis

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-08-21 DOI:10.1002/jgh3.70259

Tsuyoshi Beppu, Fumihito Hirai, Kensei Ohtsu, Masahiro Kishi, Teruyuki Takeda, Shigeyoshi Yasukawa, Noritaka Takatsu, Takashi Hisabe, Toshiharu Ueki, Kenshi Yao

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Abstract

Background

Adherence to 5-aminosalicylic acid (5-ASA), an anchor drug for ulcerative colitis (UC), affects remission maintenance. This study aimed to investigate the current status of adherence to 5-ASA and identify the factors associated with adherence.

Methods

We enrolled UC patients whose primary maintenance therapy was oral 5-ASA at our hospital between January 2017 and December 2018. The adherence status was examined using a questionnaire survey. Various factors, including patient background and disease activity, were also analyzed to identify those related to adherence. A second questionnaire with the same content was performed 1 year after the initial survey for comparison.

Results

In total, 297 patients with UC answered the first questionnaire, of which 278 answered the second questionnaire. Complete adherence rates at the time of the first and second questionnaires were 49.8% (148/297) and 55.8% (155/278), respectively. Full-time employment (p = 0.00893), eating one or two meals per day (p = 0.00641), and multiple daily doses (p = 0.0153) were significantly associated with lower adherence. The 119 patients who fully adhered to both the primary and secondary questionnaires had a significantly higher cumulative non-relapse rate at 1 year than those 159 who were not (85.7% vs. 76.1%, p = 0.0207).

Conclusions

UC patients with high adherence to 5-ASA showed a high rate of remission maintenance, so adherence should be improved by considering factors such as the number of medications taken, work status, and dietary habits.

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溃疡性结肠炎患者口服5-氨基水杨酸依从性的前瞻性问卷调查

背景：5-氨基水杨酸（5-ASA）是治疗溃疡性结肠炎（UC）的锚定药物，可影响缓解维持。本研究旨在调查5-ASA依从性的现状，并确定与依从性相关的因素。方法纳入2017年1月至2018年12月在我院以口服5-ASA为主要维持治疗的UC患者。采用问卷调查法检查依从性状况。还分析了各种因素，包括患者背景和疾病活动，以确定与依从性相关的因素。第一次问卷调查1年后再次进行问卷调查，问卷内容相同。结果共有297例UC患者回答了第一份问卷，其中278例患者回答了第二份问卷。第一次和第二次问卷调查时的完全依从率分别为49.8%（148/297）和55.8%（155/278）。全职工作（p = 0.00893）、每天吃一餐或两餐（p = 0.00641）和多次每日给药（p = 0.0153）与较低的依从性显著相关。119例完全遵守第一问卷和第二问卷的患者1年累计无复发率明显高于159例未遵守第一问卷和第二问卷的患者（85.7% vs. 76.1%, p = 0.0207）。结论UC患者5-ASA依从性高，缓解维持率高，需综合考虑用药次数、工作状态、饮食习惯等因素提高依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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