Dual-extruder 3D-printing of biodegradable subcutaneous implants for controlled drug delivery

IF 11.1 1区工程技术 Q1 ENGINEERING, MANUFACTURING

Additive manufacturing Pub Date : 2025-07-25 DOI:10.1016/j.addma.2025.104928

Bianca Brandl , Scarlett Zeiringer , Ludwig Loidl , Anbu Palanisamy , Sarah Heupl , Matthias Katschnig , Thanh Nguyen , Eva Roblegg , Martin Spoerk , Simone Eder

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引用次数: 0

Abstract

Subcutaneous implantable drug delivery systems (SIDDS) offer significant reduction in administration frequency compared to oral dosage forms, which improves patient adherence. However, current manufacturing methods, such as hot melt extrusion, offer limited flexibility for individualizing product specifications (e.g., changes in drug loading or changes in the daily dose) and for providing on-demand solutions. Here, dual-extruder fused filament fabrication was explored for the first time as an advanced manufacturing method to produce biodegradable, drug-loaded SIDDS with customizable release profiles. Seven advanced implant designs (including monolithic and core-shell type implants) were tested to study the impact of 3D-printing parameters (e.g., the internal porosity or shell thickness) on the drug release profile, confirming the suppression of burst release and the achievement of zero-order or tri-phasic release profiles. The implants were further characterized with respect to quality parameters such as shell continuity, shell thickness, and drug content. Overall, this work provides a fundamental framework to produce SIDDS with adaptable release profiles and release time frames through adjustment of 3D-printing parameters.

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双挤出机3d打印可生物降解皮下植入物用于控制药物输送

与口服剂型相比，皮下植入式给药系统（SIDDS）可显著减少给药频率，从而提高患者的依从性。然而，目前的制造方法，如热熔挤压，在个性化产品规格（例如，药物负荷的变化或每日剂量的变化）和提供按需解决方案方面提供有限的灵活性。在这里，双挤出机熔融长丝制造首次作为一种先进的制造方法进行了探索，以生产具有可定制释放轮廓的可生物降解的载药SIDDS。我们测试了7种先进的植入物设计（包括单片植入物和核壳型植入物），研究了3d打印参数（如内部孔隙度或外壳厚度）对药物释放曲线的影响，确认了对爆发释放的抑制以及零级或三相释放曲线的实现。植入物的质量参数进一步表征，如外壳连续性、外壳厚度和药物含量。总的来说，这项工作提供了一个基本框架，通过调整3d打印参数来生产具有可适应的释放概况和释放时间框架的小岛屿发展计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Additive manufacturing Materials Science-General Materials Science

CiteScore

19.80

自引率

12.70%

发文量

648

审稿时长

35 days

期刊介绍： Additive Manufacturing stands as a peer-reviewed journal dedicated to delivering high-quality research papers and reviews in the field of additive manufacturing, serving both academia and industry leaders. The journal's objective is to recognize the innovative essence of additive manufacturing and its diverse applications, providing a comprehensive overview of current developments and future prospects. The transformative potential of additive manufacturing technologies in product design and manufacturing is poised to disrupt traditional approaches. In response to this paradigm shift, a distinctive and comprehensive publication outlet was essential. Additive Manufacturing fulfills this need, offering a platform for engineers, materials scientists, and practitioners across academia and various industries to document and share innovations in these evolving technologies.