Unraveling cassia oil's efficacy in alleviating winter-triggered mood disorders in Parkinson's disease patients via aromatherapy-mediated pathways

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing Pub Date : 2025-08-15 DOI:10.1016/j.explore.2025.103240

Qiang Zhang , Peilu Zhang , Dongwei Yan

{"title":"Unraveling cassia oil's efficacy in alleviating winter-triggered mood disorders in Parkinson's disease patients via aromatherapy-mediated pathways","authors":"Qiang Zhang , Peilu Zhang , Dongwei Yan","doi":"10.1016/j.explore.2025.103240","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>This randomized controlled trial (RCT) aimed to evaluate the efficacy of Cassia Oil (CO)-based fragrance therapy in alleviating winter-aggravated mood disorders (including depression and anxiety) in Parkinson's disease (PD) patients, specifically assessing its effects on improving sleep quality and reducing fatigue-key comorbid symptoms often exacerbated in winter. Additionally, it sought to verify whether this non-pharmacological intervention could serve as a viable complementary strategy for managing seasonal symptom fluctuations in PD.</div></div><div><h3>Methods</h3><div>Eighty PD patients were randomized to receive CO inhalation therapy (2 h/day, 5 days/week for 8 weeks; <em>n</em> = 40) or standard care (<em>n</em> = 40). Outcomes included mood (Hamilton Depression Scale [HAMD], Hamilton Anxiety Scale [HAMA]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), fatigue (Fatigue Scale-14 [FS-14]). Assessments were conducted at baseline and post-treatment.</div></div><div><h3>Results</h3><div>The intervention group demonstrated significant reductions in HAMD (22.08±5.43 vs. 13.65±2.73, <em>p</em> < 0.01) and HAMA scores (17.63±4.50 vs. 12.23±0.53, <em>p</em> < 0.001), with no changes in controls (HAMD: 22.87±6.03 to 23.38±5.66, <em>p</em> = 0.72; HAMA: 16.93±3.87 to 15.95±4.55, <em>p</em> = 0.31). PSQI total scores improved significantly in the intervention group (12.20±3.09 to 0.83±0.96, <em>p</em> < 0.01), particularly in subjective sleep quality (<em>t</em> = 6.55, <em>p</em> < 0.01) and sleep latency (<em>t</em> = 5.46, <em>p</em> < 0.01).</div></div><div><h3>Conclusion</h3><div>CO-based fragrance therapy effectively improved mood, sleep quality, and fatigue in PD patients during winter, offering a novel non-pharmacological approach for seasonal symptom management.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 6","pages":"Article 103240"},"PeriodicalIF":2.2000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Explore-The Journal of Science and Healing","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1550830725001314","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This randomized controlled trial (RCT) aimed to evaluate the efficacy of Cassia Oil (CO)-based fragrance therapy in alleviating winter-aggravated mood disorders (including depression and anxiety) in Parkinson's disease (PD) patients, specifically assessing its effects on improving sleep quality and reducing fatigue-key comorbid symptoms often exacerbated in winter. Additionally, it sought to verify whether this non-pharmacological intervention could serve as a viable complementary strategy for managing seasonal symptom fluctuations in PD.

Methods

Eighty PD patients were randomized to receive CO inhalation therapy (2 h/day, 5 days/week for 8 weeks; n = 40) or standard care (n = 40). Outcomes included mood (Hamilton Depression Scale [HAMD], Hamilton Anxiety Scale [HAMA]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), fatigue (Fatigue Scale-14 [FS-14]). Assessments were conducted at baseline and post-treatment.

Results

The intervention group demonstrated significant reductions in HAMD (22.08±5.43 vs. 13.65±2.73, p < 0.01) and HAMA scores (17.63±4.50 vs. 12.23±0.53, p < 0.001), with no changes in controls (HAMD: 22.87±6.03 to 23.38±5.66, p = 0.72; HAMA: 16.93±3.87 to 15.95±4.55, p = 0.31). PSQI total scores improved significantly in the intervention group (12.20±3.09 to 0.83±0.96, p < 0.01), particularly in subjective sleep quality (t = 6.55, p < 0.01) and sleep latency (t = 5.46, p < 0.01).

Conclusion

CO-based fragrance therapy effectively improved mood, sleep quality, and fatigue in PD patients during winter, offering a novel non-pharmacological approach for seasonal symptom management.

查看原文本刊更多论文

通过芳香疗法介导的途径揭示决明子油在缓解帕金森病患者冬季引发的情绪障碍中的功效

本随机对照试验（RCT）旨在评估以桂明油（CO）为基础的香氛疗法对缓解帕金森病（PD）患者冬季加重的情绪障碍（包括抑郁和焦虑）的疗效，特别是评估其对改善睡眠质量和减轻冬季常加重的疲劳主要共病症状的影响。此外，它试图验证这种非药物干预是否可以作为一种可行的补充策略来管理PD的季节性症状波动。方法80例PD患者随机分为CO吸入治疗组（每天2小时，每周5天，共8周，n = 40）和标准治疗组（n = 40）。结果包括情绪（汉密尔顿抑郁量表[HAMD]、汉密尔顿焦虑量表[HAMA]）、睡眠质量（匹兹堡睡眠质量指数[PSQI]）、疲劳（疲劳量表-14 [FS-14]）。在基线和治疗后进行评估。结果干预组HAMD（22.08±5.43比13.65±2.73,p < 0.01）和HAMA评分（17.63±4.50比12.23±0.53,p < 0.001）显著降低，对照组无变化（HAMD: 22.87±6.03比23.38±5.66,p = 0.72; HAMA: 16.93±3.87比15.95±4.55,p = 0.31）。干预组患者PSQI总分显著改善（12.20±3.09 ~ 0.83±0.96,p < 0.01），尤其是主观睡眠质量（t = 6.55, p < 0.01）和睡眠潜伏期（t = 5.46, p < 0.01）。结论以co为基础的芳香疗法可有效改善PD患者冬季的情绪、睡眠质量和疲惫感，为季节性症状的治疗提供了一种新的非药物治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Explore-The Journal of Science and Healing 医学-全科医学与补充医学

CiteScore

3.00

自引率

8.30%

发文量

179

审稿时长

25 days

期刊介绍： EXPLORE: The Journal of Science & Healing addresses the scientific principles behind, and applications of, evidence-based healing practices from a wide variety of sources, including conventional, alternative, and cross-cultural medicine. It is an interdisciplinary journal that explores the healing arts, consciousness, spirituality, eco-environmental issues, and basic science as all these fields relate to health.