Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker

IF 3 Q3 ONCOLOGY

Advances in cancer biology - metastasis Pub Date : 2025-08-19 DOI:10.1016/j.adcanc.2025.100150

Iman Akhlaghipour , Negin Taghehchian , Meysam Moghbeli

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Abstract

Late diagnosis has a key role in therapeutic failure and tumor relapse. Therefore, assessment of the molecular tumor biology can help to introduce novel early diagnostic markers. MicroRNAs (miRNAs) have important roles in regulation of tumor cell proliferation, invasion, drug resistance, and angiogenesis. Due to the high stability of miRNAs in paraffin-embedded tissues and body fluids, they can be also used as the non-invasive markers for cancer screening and early diagnosis. According to numerous reports about the role of miR-103a in various cancers, in the present review we investigated the molecular biology of miR-103a during tumor progression. It has been reported that miR-103a has a dual function as an oncogene and tumor suppressor in various cancers. MiR-103a exerts its role in tumor progression by regulation of signaling pathways, apoptosis, cell cycle, cell metabolism, and transcription factors. This review paves the way in introducing miR-103a as a diagnostic and therapeutic marker among cancer patients following the animal studies and clinical trials.

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microRNA-103a可能作为诊断和治疗肿瘤标志物的分子病理学研究

晚期诊断在治疗失败和肿瘤复发中起关键作用。因此，对肿瘤分子生物学的评估有助于引入新的早期诊断标志物。MicroRNAs （miRNAs）在肿瘤细胞增殖、侵袭、耐药和血管生成等方面具有重要的调控作用。由于mirna在石蜡包埋组织和体液中的高稳定性，它们也可以作为癌症筛查和早期诊断的非侵入性标志物。根据大量关于miR-103a在各种癌症中的作用的报道，在本综述中，我们研究了miR-103a在肿瘤进展中的分子生物学。据报道，miR-103a在多种癌症中具有致癌基因和抑癌基因的双重功能。MiR-103a通过调控信号通路、细胞凋亡、细胞周期、细胞代谢、转录因子等在肿瘤进展中发挥作用。本综述为通过动物研究和临床试验将miR-103a引入癌症患者的诊断和治疗标记铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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