The clinical characteristics and inflammatory endotypes of chronic rhinosinusitis with nasal polyps in Southern China: A multi-center, cross sectional study.
Zhaofeng Xu, Ming Lai, Xin Luo, Wenxiang Gao, Wendong Liu, Ziqi Huang, Wufuer Jiang, Xuelan Zeng, Yang Liu, Qintai Yang, Jianbo Shi, Yinyan Lai
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引用次数: 0
Abstract
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disease characterized by prolonged symptoms and frequent recurrences. According to clinical and pathological characteristics, patients can be classified into different endotypes. Limited data exist on the endotype distribution of CRSwNP in Southern China.
Objective: This study aimed to delineate the clinical characteristics and inflammatory endotypes of CRSwNP in Southern China, with a focus on the impact of asthma and allergic comorbidities on disease severity and recurrence.
Methods: This multi-center, cross-sectional study analyzed 375 adult patients with CRSwNP from 3 hospitals in Southern China. Patients were classified into type 2 and non-type 2 endotypes based on clinical criteria, including blood eosinophil counts, serum immunoglobulin E levels, and tissue eosinophil percentages. Data on demographics, clinical symptoms, comorbidities, and histopathological features were collected. Statistical analyses identified factors associated with disease severity and recurrence.
Results: Among the 375 patients, 75.7% had type 2 CRSwNP. Patients with type 2 CRSwNP, particularly those with asthma, had more severe symptoms and lower quality of life scores than those with non-type 2 CRSwNP. Allergic rhinitis (AR) was associated with a higher risk of recurrence but not with disease severity. Middle-aged and older patients were more likely to exhibit type 2 features and asthma as a comorbidity.
Conclusions: Type 2 CRSwNP is predominant in Southern China, with significant implications for disease management. The presence of asthma as a comorbidity exacerbates symptoms and reduces quality of life. AR as a comorbidity was not relevant to the severity of CRSwNP.
期刊介绍：
The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.
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