Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study.

IF 4.3 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2025-08-07 eCollection Date: 2025-08-01 DOI:10.1016/j.waojou.2025.101103

Fumiko Okazaki, Hiroyuki Wakiguchi, Yuno Korenaga, Mototsugu Shimokawa, Tsuyoshi Tanabe, Ken Fukuda, Masanari Hasegawa, Miho Shimizu, Reiji Hirano, Tadashi Moriwake, Mai Kawamura, Hiroshi Tateishi, Ryo Kadoya, Yasumasa Tsuda, Takaomi Sekino, Norimichi Tashiro, Hirofumi Inoue, Yoshiko Nawata, Makoto Mizutani, Takashi Maki, Kenji Nakatsuka, Shunji Hasegawa

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引用次数: 0

Abstract

Background: Non-immunoglobulin E-mediated gastrointestinal food allergies (non-IgE-GI-FAs) in children with Down syndrome (DS) tend to be more severe, with some children presenting with sepsis-like symptoms. However, the epidemiology of this condition remains unknown. This study aimed to investigate the prevalence rate and clinical characteristics of non-IgE-GI-FAs in children with DS.

Methods: This study included 115 children with non-IgE-GI-FAs diagnosed at 13 hospitals in Yamaguchi Prefecture, Japan, between January 1, 2011, and December 31, 2020. The children were classified into DS and non-DS groups, and their clinical characteristics were retrospectively compared.

Results: Among the 115 children with non-IgE-GI-FAs, 7 and 108 were included in the DS and non-DS groups, respectively. During the study period, 184 children with DS were born in Yamaguchi prefecture, and 7 developed non-IgE-GI-FAs. In this study, the prevalence rate of non-IgE-GI-FAs was 3.8% (7/184) in children with DS and 0.11% (108/98,989) in children without DS. No significant differences were observed in causative foods, age at onset, age at diagnosis, or age at confirmed clinical remission between the 2 groups. Most children in both groups experienced vomiting and diarrhea, but none had hypothermia. Sepsis-like symptoms, such as lethargy (71.4% vs. 24.1%, P = 0.0150), hypotension (42.9% vs. 0.9%, P = 0.0006), and fever (57.1% and 8.3%, P = 0.0030), were significantly more common in the DS group than in the non-DS group.

Conclusions: The prevalence rate of non-IgE-GI-FAs was 3.8% in children with DS and 0.11% in children without DS. Non-IgE-GI-FAs in children with DS were significantly more severe than those in children without DS. Non-IgE-GI-FAs should be considered a differential diagnosis when sepsis-like symptoms are observed in children with DS.

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唐氏综合征儿童非免疫球蛋白e介导的胃肠道食物过敏：一项流行病学研究

背景：非免疫球蛋白e介导的胃肠道食物过敏（non-IgE-GI-FAs）在唐氏综合征（DS）患儿中往往更为严重，一些患儿表现为败血症样症状。然而，这种情况的流行病学仍然未知。本研究旨在探讨非ige - gi - fas在退行性椎体滑移患儿中的患病率及临床特点。方法：本研究纳入2011年1月1日至2020年12月31日期间在日本山口县13家医院诊断的115名非ige - gi - fas儿童。将患儿分为退行性椎体滑移组和非退行性椎体滑移组，回顾性比较两组患儿的临床特点。结果：115例非ige - gi - fas患儿中，DS组7例，非DS组108例。在研究期间，山口县出生了184名DS患儿，其中7名发生了非ige - gi - fas。本研究中，非ige - gi - fas在DS患儿中患病率为3.8%(7/184)，在非DS患儿中患病率为0.11%（108/98,989）。两组之间的致病食物、发病年龄、诊断年龄或确诊临床缓解年龄均无显著差异。两组的大多数儿童都出现了呕吐和腹泻，但没有出现体温过低。败血症样症状，如嗜睡（71.4% vs. 24.1%, P = 0.0150）、低血压（42.9% vs. 0.9%, P = 0.0006）和发烧（57.1% vs. 8.3%, P = 0.0030），在DS组中明显比非DS组更常见。结论：非ige - gi - fas在DS患儿中患病率为3.8%，在非DS患儿中患病率为0.11%。非ige - gi - fas在退行性椎体滑移患儿中的发生率明显高于非退行性椎体滑移患儿。当在DS患儿中观察到脓毒症样症状时，非ige - gi - fas应被视为鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.