A Meta-Analysis of Available Data of the Effects of Selected Whole and Powdered Fruits on Glycemia in Type 2 Diabetes.

IF 5.3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2025-08-15 DOI:10.1016/j.amjmed.2025.08.005

Nozomi Kuramoto, Junya Hironaka, Hiroshi Okada, Yuka Hasegawa, Hanako Nakajima, Takuro Okamura, Rieko Nakatani, Saori Majima, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui

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引用次数: 0

Abstract

Objective: To evaluate the effects of whole fruit-based products consumption on HbA1c levels in patients with type 2 diabetes mellitus through a systematic review and meta-analysis.

Methods: We searched PubMed, Cochrane Library, and Embase from inception to April 22, 2024, for randomized controlled trials (RCTs) examining the effects of whole fruit-based products consumption on HbA1c in type 2 diabetes mellitus (PROSPERO: CRD42024566638). A random-effects meta-analysis was performed. Mean difference (MD) and 95% confidence intervals (CIs) were calculated; heterogeneity was assessed using I².

Results: Five RCTs involving 245 participants were included. Fruit consumption significantly reduced HbA1c levels (MD, -0.33%; 95% CI, -0.54% to -0.11%; I² = 44%). FBG was also reduced (MD, -6.59 mg/dL; 95% CI, -10.59 to -2.59 mg/dL; I² = 0%), and HDL increased (MD, 2.72 mg/dL; 95% CI, 1.32 to 4.12 mg/dL; I² = 0%). One study had high risk of bias; no serious adverse events were reported.

Conclusions: Whole fruit-based products consumption may improve HbA1c, fasting blood glucose, and HDL cholesterol levels in patients with type 2 diabetes mellitus. REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OR META-ANALYSES: PROSPERO number CRD42024566638. The registration date was August 2nd, 2024.

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对2型糖尿病患者食用完整水果和粉状水果对血糖影响的meta分析

目的：通过系统综述和荟萃分析，评价全果类产品消费对2型糖尿病患者HbA1c水平的影响。方法：我们检索了PubMed、Cochrane Library和Embase，检索了从成立到2024年4月22日的随机对照试验（rct），研究了食用全水果类产品对2型糖尿病患者HbA1c的影响（PROSPERO: CRD42024566638）。进行随机效应荟萃分析。计算平均差（MD）和95%置信区间（ci）；使用I²评估异质性。结果：纳入5项随机对照试验，共245名受试者。食用水果可显著降低HbA1c水平（MD, -0.33%; 95% CI, -0.54% ~ -0.11%; I² = 44%）。FBG也降低（MD, -6.59 mg/dL; 95% CI, -10.59 ~ -2.59 mg/dL; I² = 0%），HDL升高（MD, 2.72 mg/dL; 95% CI, 1.32 ~ 4.12 mg/dL; I² = 0%）。一项研究存在高偏倚风险；无严重不良事件报告。结论：食用全水果类产品可改善2型糖尿病患者的HbA1c、空腹血糖和高密度脂蛋白胆固醇水平。登记和登记号码为系统评价或荟萃分析：普洛斯彼罗号码CRD42024566638。注册日期是2024年8月2日。

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.