Revolutionizing Breast Cancer Therapeutics: Intersecting Frontiers of Precision Medicine, Nanotechnology, and Drug Delivery Innovations.

IF 4.7 2区 医学 Q2 ONCOLOGY
Current Treatment Options in Oncology Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI:10.1007/s11864-025-01343-3
Anandini Chattopadhyay, Falak Goyal, Abhishek Sehrawat, Inderpal Singh Sidhu, Vikramdeep Monga, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti
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引用次数: 0

Abstract

Opinion statement: The ongoing challenge of addressing breast cancer, one of the most prevalent cancers and a principal cause of mortality among women globally, has reached a critical juncture with the advent of precision medicine and the promise of nanotechnology. As the scientific community's understanding of breast cancer's genomic landscape has deepened, it has become evident that a one-size-fits-all approach to treatment is obsolete. The evolution from rudimentary immunohistochemical classifications to intricate molecular profiling has ushered in an era where therapy is increasingly tailored to the individual's genetic makeup, environmental factors, and lifestyle choices. This shift towards personalized, biomarker-driven treatments not only aims to enhance prognosis but also to minimize adverse effects by meticulously matching therapy to the unique molecular characteristics of each tumor. The integration of nanotechnology, particularly through the deployment of nanoparticles for targeted drug delivery and nano-theranostics, represents a groundbreaking stride in oncological treatment. This convergence of precision medicine and nanotechnology in breast cancer care suggests a future where combination therapies and multifunctional approaches could potentially outsmart drug resistance and augment treatment efficacy. However, the path forward is fraught with challenges such as overcoming inherent tumor heterogeneity and improving the accessibility of cutting-edge treatments. The exploration of these innovative strategies in breast cancer therapeutics underscores the critical need for a multifaceted approach to cancer care, emphasizing the potential of these advances to revolutionize treatment paradigms and offer new hope to patients.

革新乳腺癌治疗:精密医学、纳米技术和药物传递创新的交叉前沿。
意见声明:随着精确医学的出现和纳米技术的前景,应对乳腺癌这一最普遍的癌症之一和全球妇女死亡的主要原因的持续挑战已达到关键时刻。随着科学界对乳腺癌基因组图谱的了解不断加深,一刀切的治疗方法显然已经过时了。从基本的免疫组织化学分类到复杂的分子图谱的进化,已经开启了一个时代,在这个时代,治疗越来越多地针对个人的基因组成、环境因素和生活方式选择。这种向个性化、生物标志物驱动治疗的转变不仅旨在提高预后,而且还通过精心匹配每种肿瘤独特的分子特征来减少不良反应。纳米技术的整合,特别是通过部署纳米粒子进行靶向药物输送和纳米治疗,代表了肿瘤治疗的突破性进展。精准医学和纳米技术在乳腺癌治疗中的融合表明,未来联合疗法和多功能方法可能会战胜耐药性,提高治疗效果。然而,前进的道路充满了挑战,如克服固有的肿瘤异质性和提高尖端治疗的可及性。乳腺癌治疗中这些创新策略的探索强调了对癌症治疗的多方面方法的迫切需要,强调了这些进步有可能彻底改变治疗范式并为患者带来新的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.10
自引率
0.00%
发文量
113
审稿时长
>12 weeks
期刊介绍: This journal aims to review the most important, recently published treatment option advances in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to facilitate worldwide approaches to cancer treatment. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as endocrine tumors, lymphomas, neuro-oncology, and cancers of the breast, head and neck, lung, skin, gastrointestinal tract, and genitourinary region. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known oncologists, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.
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