Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.

IF 3.4 4区 医学 Q2 DERMATOLOGY
Gabriela Danessa, Dion Notario, Regina Regina
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引用次数: 0

Abstract

Background Ageing is a degenerative process that affects the entire body. Skin ageing is characterised by a decrease in the levels of collagen, elastin fibre, and hyaluronic acid (HA), resulting in a loss of skin elasticity and hydration. Prior studies suggest that oral collagen supplements can help increase collagen, elastin, and HA levels, ultimately improving skin health. Objective To assess the impact of collagen-based supplements on the signs of skin ageing and determine the effective dosage. Methods This systematic review and meta-analysis utilized PubMed, Clinical Key, ProQuest, and Cochrane Library databases to identify studies published from 2010 to 2021. It includes ten randomised controlled trials (RCTs) with a total of 646 participants. Results The findings indicate that collagen supplements were statistically effective in increasing skin hydration (SMD 1.25 (CI: 0.77-1.74)) and elasticity (SMD 0.61 (CI: 0.21-1.02)). The most commonly administered dose was 4 g/day, with a median dose of 3.5 g/ day. Limitations Most of the studies could not control for weather-related factors. The findings are more applicable to females. Moderate heterogeneity (I2 = 55.5-56.5%) may limit generalisability. The risk of bias was generally unclear, and publication bias could not be assessed due to the small number of studies. Conclusion Oral administration of collagen supplement in a dose ranging from 1-10 g/day was statistically effective in increasing the skin hydration and elasticity.

胶原蛋白补充剂对皮肤水合和弹性的影响:系统回顾和荟萃分析。
衰老是一种影响整个身体的退化过程。皮肤老化的特征是胶原蛋白、弹性蛋白纤维和透明质酸(HA)水平下降,导致皮肤失去弹性和水合作用。先前的研究表明,口服胶原蛋白补充剂可以帮助增加胶原蛋白、弹性蛋白和透明质酸水平,最终改善皮肤健康。目的评价胶原蛋白补充剂对皮肤衰老的影响,确定其有效剂量。方法采用PubMed、Clinical Key、ProQuest和Cochrane Library数据库对2010年至2021年发表的研究进行系统评价和荟萃分析。它包括10个随机对照试验(rct),共有646名参与者。结果胶原蛋白补充剂在增加皮肤水合度(SMD 1.25 (CI: 0.77-1.74))和弹性(SMD 0.61 (CI: 0.21-1.02))方面具有统计学效果。最常用的给药剂量为4克/天,中位剂量为3.5克/天。大多数研究无法控制与天气有关的因素。这一发现更适用于女性。中度异质性(I2 = 55.5-56.5%)可能限制了通用性。偏倚风险一般不清楚,由于研究数量少,无法评估发表偏倚。结论口服胶原蛋白补充剂1 ~ 10g /d可显著提高皮肤水合性和弹性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.10
自引率
10.30%
发文量
247
审稿时长
6-12 weeks
期刊介绍: The Indian Association of Dermatologists, Venereologists & Leprologists (IADVL) is the national association of Indian medical specialists who manage patients with skin disorders, sexually transmitted infections (STIs) or leprosy. The current member strength of the association is about 3800. The association works for the betterment of the specialty by holding academic meetings, printing a journal and publishing a textbook. The IADVL has several state branches, each with their own office bearers, which function independently within the constitution of the IADVL. Established in 1940, the Indian Journal of Dermatology, Venereology and Leprology (IJDVL, ISSN 0378-6323) is the official publication of the IADVL (Indian Association of Dermatologists, Venereologists and Leprologists).
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