Treatment of central sleep apnea in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Clinical Sleep Medicine Pub Date : 2025-08-18 DOI:10.5664/jcsm.11860

M Safwan Badr, Rami N Khayat, J Shirine Allam, Suzanne Hyer, Reem A Mustafa, Matthew T Naughton, Susheel Patil, Grace Pien, Winfried Randerath, Christine Won

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Abstract

Introduction: This systematic review provides supporting evidence for the accompanying clinical practice guideline on the treatment of central sleep apnea (CSA) syndrome in adults.

Methods: The American Academy of Sleep Medicine commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies that compared the use of positive airway pressure therapies (PAP), non-PAP therapies, and pharmacological treatment to no treatment to improve patient-important outcomes. Statistical analyses were performed to determine the clinical meaningfulness of using various interventions to treat CSA in adults. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process was used to assess the evidence for making recommendations.

Results: The literature search resulted in 6,701 articles out of which 103 articles provided data suitable for statistical analyses. The task force provided a detailed summary of the evidence along with the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations.

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成人中枢性睡眠呼吸暂停的治疗：美国睡眠医学学会系统回顾、荟萃分析和GRADE评估。

本系统综述为成人中枢性睡眠呼吸暂停（CSA）综合征治疗的临床实践指南提供支持证据。方法：美国睡眠医学学会委托了一个睡眠医学专家工作组。进行了一项系统综述，以确定比较使用气道正压治疗（PAP）、非PAP治疗和药物治疗与不治疗以改善患者重要结局的研究。通过统计分析来确定采用各种干预措施治疗成人CSA的临床意义。建议分级评估、发展和评价（GRADE）过程用于评估提出建议的证据。结果：共检索到6701篇文献，其中103篇文献提供了适合统计分析的数据。该工作组提供了证据的详细摘要，以及证据的确定性、利益和危害的平衡、患者的价值观和偏好以及资源使用方面的考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Sleep Medicine CLINICAL NEUROLOGY-

CiteScore

6.20

自引率

7.00%

发文量

321

审稿时长

1 months

期刊介绍： Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.