Evaluation of serum ischemia-modified albumin levels in high-normal blood pressure category.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2025-07-24 eCollection Date: 2025-01-01 DOI:10.4103/jrms.jrms_43_25

Okan Tanriverdi, Alper Sercelik

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引用次数: 0

Abstract

Background: High-normal blood pressure (BP), situated inside the elevated normal range and indicative of potential hypertension, is widely acknowledged as a critical worldwide health issue. High-normal BP levels consist of a systolic measurement of 130-139 mmHg and a diastolic measurement of 85-89 mmHg. Ischemia-modified albumin (IMA) is a sign that tissues are not getting enough oxygen, which is also known as tissue hypoxia. Numerous studies indicate that IMA possesses prognostic relevance in cardiovascular diseases. Our purpose was to investigate the serum IMA levels in patients with high-normal BP.

Materials and methods: The study prospectively enrolled 50 participants with high-normal BP and 50 individuals with normal BP consecutively. Both groups' IMA levels were assessed and compared. All patients' echocardiograms were collected.

Results: The IMA values were markedly elevated in the high-normal group (P < 0.001). The research identified a significant correlation between IMA and high-normal BP, with an odds ratio of 1.725 (95% confidence interval [CI] 1.212-2.506, P < 0.001). An IMA level of 348 ng/L demonstrated a 94% accuracy in predicting high-normal BP, with a 32% accuracy overall (area under the curve = 0.942; 95% CI, 0.894-0.991; P < 0.001).

Conclusion: Our analysis demonstrated a strong correlation between IMA and high-normal BP.

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高血压患者血清缺血修饰白蛋白水平的评价。

背景：高正常血压（BP）处于正常范围内，预示着潜在的高血压，被广泛认为是一个严重的全球健康问题。高正常血压水平包括收缩期130- 139mmhg和舒张期85- 89mmhg。缺血修饰白蛋白（IMA）是组织没有得到足够氧气的标志，也被称为组织缺氧。大量研究表明，IMA在心血管疾病中具有预后相关性。我们的目的是研究血压高正常患者的血清IMA水平。材料与方法：本研究前瞻性地连续招募50例血压高正常者和50例血压正常者。对两组的IMA水平进行评估和比较。收集所有患者的超声心动图。结果：高正常组IMA值明显升高（P < 0.001）。研究发现IMA与高正常血压之间存在显著相关性，比值比为1.725（95%可信区间[CI] 1.212-2.506, P < 0.001）。IMA水平为348 ng/L时，预测高正常血压的准确率为94%，总体准确率为32%（曲线下面积= 0.942;95% CI, 0.894-0.991; P < 0.001）。结论：我们的分析表明IMA和高正常血压之间有很强的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.