The implication of abnormal routine coagulation parameters in Dabie bandavirus infection.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Tianzhu Zhang, Huan Bai, Bin Wang, Dengju Li, Ning Tang
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引用次数: 0

Abstract

Prolonged activated partial thromboplastin time (APTT) and thrombin time (TT), normal prothrombin time (PT) and elevated D-dimer level are typical manifestation of routine coagulation parameters in patients infected with Dabie bandavirus (DBV), infection-induced coagulation activation and consumption, and a heparin-like effect due to endogenous heparan are the common explanations. To understand the exact implication of abnormal coagulation parameters in patients infected with DBV and their correlation with bleeding tendency and prognosis. One hundred and twenty-one consecutive DBV-infected patients were enrolled in this prospective, single-center, observational study. Routine coagulation parameters, levels of heparan sulfate (HS) and thrombin-antithrombin (TAT) complex, and thrombin generation (TG) test of these patients on admission were detected, and their hemorrhagic events during hospitalization were recorded. In the enrolled patients, both of APTT and TT were significantly positively correlated with HS, while significantly negatively correlated with endogenous thrombin potential (ETP) of TG test (p < .05). In addition, there was a strong correlation between D-dimer and TAT (r = 0.841). The patients with hemorrhagic events during hospitalization had significantly higher APTT and D-dimer and lower platelet count and ETP on admission than those without, and only ETP was the independent predictor (p < .05). The prolongation of APTT and TT of DBV-infected patients reflected decreased TG potential, and increased D-dimer level reflected an increase in thrombin activity. An accurate understanding of the implication of these coagulation parameters is helpful for the rational management of DBV infection.

大别班达病毒感染血凝指标异常的意义。
大别班病毒(DBV)感染患者凝血常规参数的典型表现为活化部分凝血活素时间(APTT)和凝血酶时间(TT)延长,凝血酶原时间(PT)正常,d -二聚体水平升高,感染诱导凝血激活和消耗,内源性肝素类肝素作用是常见的解释。了解DBV感染患者凝血参数异常的确切意义及其与出血倾向和预后的关系。121名连续的dbv感染患者被纳入这项前瞻性、单中心、观察性研究。检测患者入院时的常规凝血参数、硫酸肝素(HS)、凝血酶-抗凝血酶(TAT)复合物水平、凝血酶生成(TG)试验,并记录住院期间的出血事件。在入选患者中,APTT、TT与HS呈显著正相关,与TG内源性凝血酶电位(ETP)呈显著负相关(p r = 0.841)。住院期间有出血事件的患者入院时APTT和d -二聚体明显高于无出血事件的患者,血小板计数和ETP明显低于无出血事件的患者,且ETP是唯一的独立预测因子(p
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来源期刊
CiteScore
3.50
自引率
4.80%
发文量
85
审稿时长
4-8 weeks
期刊介绍: The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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