Tianzhu Zhang, Huan Bai, Bin Wang, Dengju Li, Ning Tang
{"title":"The implication of abnormal routine coagulation parameters in Dabie bandavirus infection.","authors":"Tianzhu Zhang, Huan Bai, Bin Wang, Dengju Li, Ning Tang","doi":"10.1080/00365513.2025.2548013","DOIUrl":null,"url":null,"abstract":"<p><p>Prolonged activated partial thromboplastin time (APTT) and thrombin time (TT), normal prothrombin time (PT) and elevated D-dimer level are typical manifestation of routine coagulation parameters in patients infected with Dabie bandavirus (DBV), infection-induced coagulation activation and consumption, and a heparin-like effect due to endogenous heparan are the common explanations. To understand the exact implication of abnormal coagulation parameters in patients infected with DBV and their correlation with bleeding tendency and prognosis. One hundred and twenty-one consecutive DBV-infected patients were enrolled in this prospective, single-center, observational study. Routine coagulation parameters, levels of heparan sulfate (HS) and thrombin-antithrombin (TAT) complex, and thrombin generation (TG) test of these patients on admission were detected, and their hemorrhagic events during hospitalization were recorded. In the enrolled patients, both of APTT and TT were significantly positively correlated with HS, while significantly negatively correlated with endogenous thrombin potential (ETP) of TG test (<i>p</i> < .05). In addition, there was a strong correlation between D-dimer and TAT (<i>r</i> = 0.841). The patients with hemorrhagic events during hospitalization had significantly higher APTT and D-dimer and lower platelet count and ETP on admission than those without, and only ETP was the independent predictor (<i>p</i> < .05). The prolongation of APTT and TT of DBV-infected patients reflected decreased TG potential, and increased D-dimer level reflected an increase in thrombin activity. An accurate understanding of the implication of these coagulation parameters is helpful for the rational management of DBV infection.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-6"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Clinical & Laboratory Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00365513.2025.2548013","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Prolonged activated partial thromboplastin time (APTT) and thrombin time (TT), normal prothrombin time (PT) and elevated D-dimer level are typical manifestation of routine coagulation parameters in patients infected with Dabie bandavirus (DBV), infection-induced coagulation activation and consumption, and a heparin-like effect due to endogenous heparan are the common explanations. To understand the exact implication of abnormal coagulation parameters in patients infected with DBV and their correlation with bleeding tendency and prognosis. One hundred and twenty-one consecutive DBV-infected patients were enrolled in this prospective, single-center, observational study. Routine coagulation parameters, levels of heparan sulfate (HS) and thrombin-antithrombin (TAT) complex, and thrombin generation (TG) test of these patients on admission were detected, and their hemorrhagic events during hospitalization were recorded. In the enrolled patients, both of APTT and TT were significantly positively correlated with HS, while significantly negatively correlated with endogenous thrombin potential (ETP) of TG test (p < .05). In addition, there was a strong correlation between D-dimer and TAT (r = 0.841). The patients with hemorrhagic events during hospitalization had significantly higher APTT and D-dimer and lower platelet count and ETP on admission than those without, and only ETP was the independent predictor (p < .05). The prolongation of APTT and TT of DBV-infected patients reflected decreased TG potential, and increased D-dimer level reflected an increase in thrombin activity. An accurate understanding of the implication of these coagulation parameters is helpful for the rational management of DBV infection.
期刊介绍:
The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry.
The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.