Associations of digestive diseases exposure and lifestyle factors with Parkinson's disease.

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-08-18 DOI:10.1038/s41531-025-01098-6

Kaitai Yang, Ruitian Zeng, Yiling Zheng, Siqi Zhong, Jiani Wang, Xinxi Yu, Huilin Zhong, Xuanjie Chen, Yisen Shi, Fabin Lin, Qinyong Ye, Ning Sun, Guoen Cai

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Abstract

Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson's disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This study analyzed data from 501,483 participants, including 907 PD cases. Cox models revealed that digestive diseases were significantly associated with an increased PD risk (HR = 1.43). Eleven digestive diseases were linked to PD, with lifestyle factors such as sleep patterns and diet reducing PD risk. Notably, interactions between Non-alcoholic Fatty Liver Disease (NAFLD) and sleep (P-int = 0.0119), and Crohn's disease and dietary diversity (P-int = 0.0081) were observed. Population attributable fraction (PAF) analysis indicated that eliminating exposure to gastroesophageal reflux disease (GERD), gastritis and duodenitis, and gallbladder and biliary diseases could reduce PD cases by approximately 8.9%, 7.9%, and 3.8%, respectively. These findings emphasize the role of digestive diseases and lifestyle in PD risk.

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消化系统疾病暴露和生活方式因素与帕金森病的关系

新出现的证据强调了胃肠道（GI）功能障碍在帕金森病（PD）中的重要性。虽然炎症性肠病（IBD）与PD有关，但与其他胃肠道疾病的关系尚不清楚。这项研究分析了来自501483名参与者的数据，其中包括907例PD病例。Cox模型显示，消化系统疾病与PD风险增加显著相关（HR = 1.43）。11种消化系统疾病与帕金森病有关，而睡眠模式和饮食等生活方式因素可降低患帕金森病的风险。值得注意的是，非酒精性脂肪性肝病（NAFLD）与睡眠（P-int = 0.0119）、克罗恩病与饮食多样性（P-int = 0.0081）之间存在相互作用。人群归因分数（PAF）分析表明，消除胃食管反流病（GERD）、胃炎和十二指肠炎以及胆囊和胆道疾病的暴露可使PD病例分别减少约8.9%、7.9%和3.8%。这些发现强调了消化系统疾病和生活方式在帕金森病风险中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.