Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson's disease.

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-08-18 DOI:10.1038/s41531-025-01106-9

Haiying Zhang, Yang Zhao, Yi Chen, Yuanyuan Feng, Bo Shen, Shuangshuang Dong, Jun Zhu, Xu Jiang, Dongfeng Li, Yaning Chen, Feng Han, Li Zhang

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Abstract

Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson's disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is associated with VH in PD patients remains unclear. We investigated the association between the number of MH and VH in 372 PD patients. Log-binomial regressions showed that individuals with multiple MH had a significantly higher prevalence of VH (RR = 2.08, 95% CI: 1.11-3.90 for 2 MH; RR = 6.20, 95% CI: 3.40-11.31 for 3 MH), while those with only one MH had a similar VH prevalence compared to those without MH (RR = 1.08, 95% CI: 0.53-2.21). Women exhibited stronger associations than men. These findings emphasize the importance of quantifying MH subtypes when assessing hallucinations, though their potential utility as predictive markers of disease progression and targets for early intervention requires validation through longitudinal studies.

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帕金森病中轻微幻觉与结构良好的视幻觉数量的关系。

轻微幻觉（MH）包括三种亚型（存在幻觉、通道幻觉和视觉幻觉），通常出现在帕金森病（PD）的早期阶段，早于结构良好的视觉幻觉（VH）的发作。PD患者的MH数量是否与VH相关尚不清楚。我们调查了372例PD患者中MH和VH数量之间的关系。对数二项回归分析显示，患有多种MH的个体的VH患病率显著高于其他个体（2种MH的RR = 2.08, 95% CI: 1.11-3.90； 3种MH的RR = 6.20, 95% CI: 3.40-11.31），而只有一种MH的个体的VH患病率与没有MH的个体相似（RR = 1.08, 95% CI: 0.53-2.21）。女性比男性表现出更强的联想。这些发现强调了在评估幻觉时量化MH亚型的重要性，尽管它们作为疾病进展的预测标记和早期干预目标的潜在效用需要通过纵向研究来验证。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.