Yi He, Fahang Yi, Ping Tang, Kaiqiang Xiao, Liang Wang
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引用次数: 0
Abstract
Anti-GABAB receptor encephalitis coexistence with autoimmune polyendocrine syndrome (APS) has not been reported. We present the first case of anti-GABAB receptor encephalitis coexisting with APS type III. A 64-year-old male presented with recurrent convulsions with loss of consciousness. Diagnostic evaluation revealed positive anti-GABAB receptor antibodies, elevated HbA1cand fasting blood glucose, and glutamic aciddecarboxylase antibodies (GAD-Ab), hypothyroidism with positive thyroglobulin and peroxidase antibody. The patient demonstrated complete diagnostic criteria for both anti-GABAB receptor encephalitis and APS type III. A Combination therapy with pulse corticosteroids, intravenous immunoglobulin, levothyroxine, and insulin achieved significant clinical improvement. The findings expand the spectrum of autoimmune overlap syndromes and highlight diagnostic challenges in patients presenting with concurrent neurological and endocrine dysfunction.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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