Characteristics of SAA, the SII and NT-proBNP levels in patients with ACI and their value in evaluating the prognosis of thrombolytic therapy.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-19 DOI:10.1080/01616412.2025.2549030

Xianshi Yang, Ailan Pang, Wei Liu, Hong Xu

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引用次数: 0

Abstract

Objective: To explore the features of serum amyloid A (SAA), the systemic immune inflammation index (SII), and N-terminal B-type natriuretic peptide (NT-proBNP) among individuals suffering from acute cerebral infarction (ACI), as well as their potential significance in assessing the adverse outcomes of thrombolytic treatment.

Methods: A total of 122 patients with ACI who underwent thrombolytic therapy were included in this single-center retrospective study. Patients were categorized into short-term good prognosis (n = 81) and short-term adverse outcomes (n = 41) groups on the basis of their prognosis within 6 months after the procedure. Risk factors for poor short-term prognosis after thrombolytic therapy in ACI patients were screened via regression analysis, and the predictive value of each risk factor was assessed via receiver operating characteristic (ROC) curves.

Results: Preoperative SAA, NT-proBNP, Hcy, CRP, and the SII were significantly higher in the short-term adverse outcomes group than in the good prognosis group (p < 0.05). Specifically, the adverse outcomes group had higher mean levels of SAA, NT-proBNP, and SII (p < 0.001). The combined model (SAA, NT-proBNP, and the SII) had high predictive accuracy, with an AUC of 0.957 (p < 0.05).

Conclusion: Pretreatment SAA, SII, and NT-proBNP levels are strongly correlated with adverse short-term outcomes of ACI patients following thrombolytic therapy.

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ACI患者SAA、SII和NT-proBNP水平的特点及其对溶栓治疗预后的评价

目的：探讨急性脑梗死（ACI）患者血清淀粉样蛋白A （SAA）、全身免疫炎症指数（SII）、n端b型利钠肽（NT-proBNP）的变化特征及其在溶栓治疗不良结局评估中的潜在意义。方法：本单中心回顾性研究纳入122例接受溶栓治疗的ACI患者。根据患者术后6个月内的预后情况，将患者分为短期预后良好组（n = 81）和短期预后不良组（n = 41）。通过回归分析筛选ACI患者溶栓治疗后短期预后不良的危险因素，并通过受试者工作特征（ROC）曲线评估各危险因素的预测值。结果：短期不良结局组术前SAA、NT-proBNP、Hcy、CRP、SII水平明显高于预后良好组（p p p）。结论：预处理SAA、SII、NT-proBNP水平与ACI患者溶栓治疗后短期不良结局密切相关。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.