Association Between Soy Product Intake and Insomnia in Chinese Middle-Aged and Older Adults: A Cross-Sectional Study.

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S506431

Lanrong Sun, Jiaying Lao, Haihui Guo, Jinzhong Xu, Yu-Hsin Chen, Xingguang Luo, Shencong He, Weiming Hu, Fan Wang, Li Chen, Yanlong Liu, Qizeng Wang, Wenhui Lin

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Abstract

Background and objective: Insomnia has various adverse effects on middle-aged and older adults. Improving insomnia by adjusting diet has attracted attention. This study investigated the relationship between soy product intake and insomnia in middle-aged and older adults and explored the role of inflammatory factors.

Methods: The study included 877 middle-aged and older adults aged ≥45 years which from general patients who made an appointment or were admitted to the cardiology department at Wenling Hospital in Taizhou City. The proportion of female participants is 35.01%. Soy product intake was assessed using the Food Frequency Questionnaire (FFQ), sleep was quantified using the Insomnia Severity Index (ISI). The median (IQR) of soy product intake is ≤1 time per week (≤1 time per week, 2-6 times per week) and the mean/SD value of insomnia score is 5.43/5.13.

Results: In Chinese middle-aged and older adults, soy product intake was negatively correlated with insomnia (|r|s ≥ 0.117, ps < 0.001), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and triglyceride (TG) levels (adjusted β: -0.139, 95% CI: -0.265 to -0.012; β: -0.049, 95% CI: -0.091 to -0.006; β: -0.043, 95% CI: -0.085 to -0, respectively). There was no significant correlation between soy product intake and White Blood Cell (WBC), Absolute Neutrophil Count (GRAM), Platelet Count (PLT), Interleukin-1β (IL-1β), Interleukin-2 (IL-2), Interleukin-6 (IL-6), Hemoglobin (Hb), Red Blood Cell (RBC), Low-Density Lipoprotein Cholesterol (LDL-C), High-Density Lipoprotein Cholesterol (HDL-C) and Total Cholesterol (TC) levels.

Conclusion: Lower levels of soy product intake are associated with higher rates of insomnia in the middle-aged and older adults. Additionally, soy product intake is negatively correlated with peripheral blood CRP, TNF-α and TG levels. This study provides a new clinical perspective for middle-aged and older adults to enhance sleep through a balanced diet, wherein the inflammation and lipid may play a potentially crucial role.

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中国中老年人豆制品摄入与失眠之间的关系：一项横断面研究。

背景与目的：失眠对中老年人有多种不良影响。通过调整饮食来改善失眠引起了人们的关注。本研究探讨了中老年人豆制品摄入与失眠的关系，并探讨了炎症因素在其中的作用。方法：选取泰州市温岭医院心内科预约就诊或住院的普通患者877例年龄≥45岁的中老年人为研究对象。女性参与比例为35.01%。使用食物频率问卷（FFQ）评估豆制品摄入量，使用失眠严重程度指数（ISI）量化睡眠。豆制品摄入的中位数（IQR）为≤1次/周（≤1次/周，2-6次/周），失眠评分的均值/SD值为5.43/5.13。结果：在中国中老年人中，豆制品摄入量与失眠（|r|s≥0.117,ps < 0.001）、c反应蛋白（CRP）、肿瘤坏死因子-α (TNF-α)和甘油三酯（TG）水平呈负相关（调整后的β: -0.139, 95% CI: -0.265 ~ -0.012; β: -0.049, 95% CI: -0.091 ~ -0.006; β: -0.043, 95% CI: -0.085 ~ -0）。豆制品摄入量与小鼠白细胞（WBC）、绝对中性粒细胞计数（GRAM）、血小板计数（PLT）、白细胞介素-1β (IL-1β)、白细胞介素-2 （IL-2）、白细胞介素-6 （IL-6）、血红蛋白（Hb）、红细胞（RBC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）水平无显著相关性。结论：在中老年人群中，豆制品摄入量较低与失眠率较高有关。此外，豆制品摄入量与外周血CRP、TNF-α和TG水平呈负相关。这项研究为中老年人通过均衡饮食来增强睡眠提供了新的临床视角，其中炎症和脂质可能起着潜在的关键作用。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.